ArticleEnvironmental health perspectives2017
Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Seasonal Antimicrobial Activity of the Airway: Post-Hoc Analysis of a Randomized Placebo-Controlled Double-Blind Trial.Nutrients · 2020Trial
- Assessment of cytotoxicity and genomic instability induced by coal-derived nanoparticles in V79 and HaCaT Cells.Archives of toxicology · 2026Article
- Methylation modification of coal gasification fine slag for enhanced organic dye adsorption in wastewater.RSC advances · 2026Article
- Atmosphere particulate matter and respiratory diseases during COVID-19 in Korea.Scientific reports · 2024Article
- Tension as a key factor in skin responses to pollution.Scientific reports · 2023Article
- Particulate matter impairs immune system function by up-regulating inflammatory pathways and decreasing pathogen response gene expression.Scientific reports · 2023Article
- Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission.American journal of respiratory and critical care medicine · 2022Review
- Article
- Role of Innate Immune System in Environmental Lung Diseases.Current allergy and asthma reports · 2021Review
- Particulate air pollution and respiratory Haemophilus influenzae infection in Mianyang, southwest China.Environmental science and pollution research international · 2021Article
- SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?Annals of the New York Academy of Sciences · 2021Review
- Lung function of primary cooks using LPG or biomass and the effect of particulate matter on airway epithelial barrier integrity.Environmental research · 2020Article
- Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD).The World Allergy Organization journal · 2020Review
- PMParticle and fibre toxicology · 2020Article
- Oral antimicrobial activity weakened in children with electronic waste lead exposure.Environmental science and pollution research international · 2020Article
- Mechanism of ambient particulate matter and respiratory infections.Journal of thoracic disease · 2020Article
- The Impact of PMFrontiers in cell and developmental biology · 2020Review
- Temporal Cross-Correlations between Ambient Air Pollutants and Seasonality of Tuberculosis: A Time-Series Analysis.International journal of environmental research and public health · 2019Article
- Indoor Particulate Matter From Smoker Homes Induces Bacterial Growth, Biofilm Formation, and Impairs Airway Antimicrobial Activity. A Pilot Study.Frontiers in public health · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundSustained exposure to ambient particulate matter (PM) is a global cause of mortality. Coal fly ash (CFA) is a byproduct of coal combustion and is a source of anthropogenic PM with worldwide health relevance. The airway epithelia are lined with fluid called airway surface liquid (ASL), which contains antimicrobial proteins and peptides (AMPs). Cationic AMPs bind negatively charged bacteria to exert their antimicrobial activity. PM arriving in the airways could potentially interact with AMPs in the ASL to affect their antimicrobial activity.
objectivesWe hypothesized that PM can interact with ASL AMPs to impair their antimicrobial activity.
methodsWe exposed pig and human airway explants, pig and human ASL, and the human cationic AMPs β-defensin-3, LL-37, and lysozyme to CFA or control. Thereafter, we assessed the antimicrobial activity of exposed airway samples using both bioluminescence and standard colony-forming unit assays. We investigated PM-AMP electrostatic interaction by attenuated total reflection Fourier-transform infrared spectroscopy and measuring the zeta potential. We also studied the adsorption of AMPs on PM.
resultsWe found increased bacterial survival in CFA-exposed airway explants, ASL, and AMPs. In addition, we report that PM with a negative surface charge can adsorb cationic AMPs and form negative particle-protein complexes.
conclusionWe propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876.
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