Evidence map›Paper›PMID 28696203›Full record

ArticleeLife2017

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria.

John C Whitney, S Brook Peterson, Jungyun Kim, Manuel Pazos, Adrian J Verster, Matthew C Radey, Hemantha D Kulasekara, Mary Q Ching, Nathan P Bullen, Diane Bryant and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 194 citations in OpenAlex.

  1. Article
  2. An endonuclease V protectsbioRxiv : the preprint server for biology · 2026
    Article
  3. Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. TheMicrobiology (Reading, England) · 2025
    Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

John C WhitneyDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0002-4517-8836
S Brook PetersonDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0003-2648-0965
Jungyun KimDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0003-3793-4264
Manuel PazosCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, United Kingdom.
Adrian J VersterDepartment of Genome Sciences, University of Washington, Seattle, United States.
Matthew C RadeyDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Hemantha D KulasekaraDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Mary Q ChingDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Nathan P BullenMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Diane BryantExperimental Systems Group, Advanced Light Source, Berkeley, United States.
Young Ah GooNorthwestern Proteomics Core Facility, Northwestern University, Chicago, United States.
Michael G SuretteMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Elhanan BorensteinDepartment of Genome Sciences, University of Washington, Seattle, United States.
Waldemar VollmerCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, United Kingdom.
Joseph D MougousDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0002-5417-4861
University of Washington · USNewcastle University · GBAdvanced Light SourceHoward Hughes Medical Institute · USMcMaster University · CANorthwestern University · USPopulation Health Research Institute · CASanta Fe Institute · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Type VI secretion effectors and interbacterial competition in vivoR01AI080609 · NIAID · YALE UNIVERSITY · PI MOUGOUS, JOSEPH DAVID · 2009 to 2025
$6.7M
A Computational Framework for Designing Microbiome ManipulationDP2AT007802 · NCCIH · UNIVERSITY OF WASHINGTON · PI BORENSTEIN, ELHANAN · 2012 to 2012
$2.3M
CIHRHoward Hughes Medical InstituteMedical Research Council MR/N002679/1Medical Research Council MR/N0026791/1NCCIH NIH HHS DP2 AT007802NCI NIH HHS P30 CA060553NIAID NIH HHS R01 AI080609NIGMS NIH HHS P41 GM108569
6 · The paper itself

Abstract

The Firmicutes are a phylum of bacteria that dominate numerous polymicrobial habitats of importance to human health and industry. Although these communities are often densely colonized, a broadly distributed contact-dependent mechanism of interbacterial antagonism utilized by Firmicutes has not been elucidated. Here we show that proteins belonging to the LXG polymorphic toxin family present in

Indexed as

AntibiosisBacterial AdhesionBacterial ToxinsCrystallography, X-RayHumansMicrobial ViabilityModels, MolecularProtein ConformationStreptococcus intermediusBacterial ToxinsFirmicuteinfectious diseasemicrobiologypolymorphictype VII secretion

Identifiers

PMID28696203
PMCPMC5555719
OpenAlexW2736014558

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.