Evidence map›Paper›PMID 28695825›Full record

ArticleeLife2017

Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing

Peter J Klover, Rajesh L Thangapazham, Jiro Kato, Ji-An Wang, Stasia A Anderson, Victoria Hoffmann, Wendy K Steagall, Shaowei Li, Elizabeth McCart, Neera Nathan and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis.International journal of molecular sciences · 2021
    Review
  6. Inactivation ofAmerican journal of physiology. Renal physiology · 2019
    Article
  7. The Lymphangioleiomyomatosis Lung Cell and Its Human Cell Models.American journal of respiratory cell and molecular biology · 2018
    Review
  8. Fibrous cephalic plaques in tuberous sclerosis complex.Journal of the American Academy of Dermatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Peter J KloverDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Rajesh L ThangapazhamDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Jiro KatoCardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Ji-An WangDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Stasia A AndersonCardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Victoria HoffmannDiagnostic and Research Services Branch, National Institutes of Health, Bethesda, United States.
Wendy K SteagallCardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Shaowei LiDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Elizabeth McCartDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Neera NathanDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Joshua D BernstockDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.
Matthew D WilkersonDepartment of Anatomy Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, United States.
Clifton L DalgardDepartment of Anatomy Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, United States.
Joel MossCardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Thomas N DarlingDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, United States.ORCID 0000-0002-5161-1974
Uniformed Services University of the Health Sciences · USNational Institutes of Health · US

Funding

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)ZIAHL002541 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MOSS, JOEL · 2009 to 2025
$47.7M
Animal MRI/Imaging CoreZICHL005909 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ANDERSON, STASIA · 2010 to 2019
$5.3M
Regulation of Dermal Fibroblasts in Skin Regeneration and HealingR01AR062080 · NIAMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI DARLING, THOMAS N · 2012 to 2016
$1.7M
NIAMS NIH HHS R01 AR062080
6 · The paper itself

Abstract

Increased mTORC1 signaling from

Indexed as

AnimalsBlood ProteinsGalectin 3GalectinsHumansMechanistic Target of Rapamycin Complex 1Mesenchymal Stem CellsMiceMice, KnockoutSkin NeoplasmsTuberous Sclerosis Complex 2 ProteinTumor Suppressor ProteinsBlood ProteinsGalectin 3GalectinsLGALS3 protein, humanLgals3 protein, mouseMechanistic Target of Rapamycin Complex 1TSC2 protein, humanTsc2 protein, mouseTuberous Sclerosis Complex 2 ProteinTumor Suppressor Proteinscancer biologygalectin-3humanhuman biologymedicinemousemTORC1tuberous sclerosis complex

Identifiers

PMID28695825
PMCPMC5505700
OpenAlexW2735194210

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.