ArticleeLife2017
A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Sexual dimorphism in epidermal stem cell dynamics.Nature · 2026Article
- Whole-Genome Resequencing Reveals Selection Signatures Associated With Lambskin Patterns in Hu Sheep.Animal genetics · 2026Article
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- GPRC6A-Duox1 Axis Regulates the Hair Cycle Through HTissue engineering and regenerative medicine · 2026Article
- Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice.JID innovations : skin science from molecules to population health · 2026Article
- Article
- Translational characterization of a house dust mite-induced murine model of dermatitis.Scientific reports · 2026Article
- Studying Hair Growth in Mice: Synchronization of Hair Follicle Growth by Depilation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- scTsI: an effective two-stage imputation method for single-cell RNA-seq data.Briefings in bioinformatics · 2025Article
- Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle.International journal of molecular sciences · 2025Article
- Superstable lipid vacuoles endow cartilage with its shape and biomechanics.Science (New York, N.Y.) · 2025Article
- Review
- Local and systemic mechanisms that control the hair follicle stem cell niche.Nature reviews. Molecular cell biology · 2024Review
- Studying Hair Growth Cycle and its Effects on Mouse Skin.The Journal of investigative dermatology · 2023Article
- MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- IRX5 promotes DNA damage repair and activation of hair follicle stem cells.Stem cell reports · 2023Article
- A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in A Blinded Clinical Trial.Journal of clinical medicine · 2023Article
- Modeling of ionizing radiation induced hair follicle regenerative dynamics.Journal of theoretical biology · 2022Article
- The origins of skin diversity: lessons from dermal fibroblasts.Development (Cambridge, England) · 2022Article
Corrections and comments
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Authors and funding
32 authors at 7 institutions in 5 countries.
Funding
Abstract
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.