Evidence map›Paper›PMID 28695822›Full record

ArticleeLife2017

Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour and 12 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 114 citations in OpenAlex.

  1. Clonazepam repurposing inJournal of medical genetics · 2025
    Trial
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Chromatin remodellers as therapeutic targets.Nature reviews. Drug discovery · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

Cemre CelenChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-8308-3750
Jen-Chieh ChuangChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Xin LuoChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Nadine NijemDepartments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States.
Angela K WalkerDepartments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, United States.
Fei ChenChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Shuyuan ZhangChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Andrew S ChungChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Liem H NguyenChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Ibrahim NassourChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Albert BudhipramonoChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Xuxu SunChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Levinus A BokDepartment of Pediatrics, Máxima Medical Center, Veldhoven, The Netherlands.
Meriel McEntagartMedical Genetics, St George's University Hospitals, NHS Foundation Trust, United Kingdom Caroline Brain, Endocrinology, Great Ormond Street Hospital for Children, London, United Kingdom.
Evelien F GeversWilliam Harvey Research Institute, Barts and the London, Queen Mary University of London, London, United Kingdom.
Shari G BirnbaumDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, United States.
Amelia J EischDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, and Mahoney Institute of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Craig M PowellDepartments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, United States.
Woo-Ping GeChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Gijs We SantenDepartment of Clinical genetics, Leiden University Medical Center, Leiden, The Netherlands.
Maria ChahrourDepartments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States.
Hao ZhuChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-8417-9698
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · USChildren's Hospital of Philadelphia · USGreat Ormond Street Hospital · GBLeiden University Medical Center · NLQueen Mary University of London · GBRadboud University Nijmegen · NL

Funding

Basic Science Training Program in Drug Abuse ResearchT32DA007290 · NIDA · YALE UNIVERSITY · PI SELF, DAVID W · 1992 to 2017
$6.7M
NOVEL GENETIC MODELS OF AUTISMR01HD069560 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI POWELL, CRAIG M · 2011 to 2020
$4.8M
Reactivation of embryonic growth programs in liver cancerR01CA190525 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2015 to 2019
$1.8M
Striatal synaptic Abnormalities in Models of AutismR01MH093697 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI POWELL, CRAIG M · 2012 to 2015
$1.6M
New Horizons in Adult NeurogenesisK02DA023555 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI EISCH, AMELIA J · 2007 to 2017
$1.1M
Metabolic roles for Lin28-let-7 miRNA pathway in sarcoma tumorigenesisK08CA157727 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2011 to 2015
$807k
Local Proliferation of Glia and their Interaction with Blood VesselsR00NS073735 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI GE, WOO-PING · 2014 to 2016
$731k
Molecular and chemogenetic control of dentate gyrus inputs: a novel approach to combat depression-like behaviorR21MH107945 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI EISCH, AMELIA J · 2015 to 2016
$451k
An optogenetic approach to study axonal repair in the brainR21NS099950 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI GE, WOO-PING · 2016 to 2017
$446k
Cdk5 and adult hippocampal neurogenesisR21DA023701 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI EISCH, AMELIA J · 2008 to 2009
$432k
Howard Hughes Medical InstituteNCI NIH HHS K08 CA157727NCI NIH HHS R01 CA190525NICHD NIH HHS R01 HD069560NIDA NIH HHS K02 DA023555NIDA NIH HHS R21 DA023701NIDA NIH HHS T32 DA007290NIMH NIH HHS R01 MH093697NIMH NIH HHS R21 MH107945NINDS NIH HHS R00 NS073735NINDS NIH HHS R21 NS099950
6 · The paper itself

Abstract

Sequencing studies have implicated haploinsufficiency of

Indexed as

HaploinsufficiencyAnimalsBehavior, AnimalBrainDevelopmental DisabilitiesDisease Models, AnimalGene Expression RegulationGrowth Hormone-Releasing HormoneHeterozygoteInsulin-Like Growth Factor IMental DisordersMiceProtein Serine-Threonine KinasesTranscription FactorsArid1b protein, mouseGrowth Hormone-Releasing Hormoneinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IProtein Serine-Threonine KinasesSnrk protein, mouseTranscription Factorsautism spectrum disordersCoffin-Siris syndromeendocrinologyexperimental models of diseasehumanhuman biologymedicinemouseneurodevelopmental disordersneuroendocrine diseasesneuroscience

Identifiers

PMID28695822
PMCPMC5515576
OpenAlexW2734654523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.