Evidence map›Paper›PMID 28695754›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain.

Philippe Bonnin, Julien Pansiot, Elise Paven, Maxime Eloi, Sylvain Renolleau, Olivier Baud, Pierre-Louis Leger, Christiane Charriaut-Marlangue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Philippe Bonnin1 Université Sorbonne Paris Cité, Paris, France.
Julien Pansiot1 Université Sorbonne Paris Cité, Paris, France.
Elise Paven1 Université Sorbonne Paris Cité, Paris, France.
Maxime Eloi1 Université Sorbonne Paris Cité, Paris, France.
Sylvain Renolleau4 Université René Descartes, AP-HP, Hôpital Necker, PICU Paris, France.
Olivier Baud1 Université Sorbonne Paris Cité, Paris, France.
Pierre-Louis Leger1 Université Sorbonne Paris Cité, Paris, France.
Christiane Charriaut-Marlangue1 Université Sorbonne Paris Cité, Paris, France.
Sorbonne Université · FRUniversité Paris Cité · FRInserm · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our objective was to determine whether controlled reflow on one side and/or the other side after bilateral carotid occlusion release could reduce cell death in focal ischemic P14 rats. Arterial blood flow was measured using ultrasonography. Cell death, inflammation and nitrotyrosine were measured using immunofluorescence. When reflow was first induced in the contralateral side, we observed improved outcome markers compared with those when reflow was first induced in the ipsilateral side and/or simultaneous reflow was induced in both sides. Our data suggest that progressive rerouting of arterial flow through the circle of Willis toward the ischemic site reduced cell death.

Indexed as

AnimalsBrain IschemiaCell DeathCerebral ArteriesCerebrovascular CirculationCyclooxygenase 2Disease Models, AnimalProstaglandin-E SynthasesRats, WistarReperfusionReperfusion InjuryTreatment OutcomeTyrosineUltrasonography3-nitrotyrosineCyclooxygenase 2Prostaglandin-E SynthasesPtges protein, ratPtgs2 protein, ratTyrosinearterial re-flowcell deathIschemic strokemacrocirculation

Identifiers

PMID28695754
PMCPMC5584705
OpenAlexW2751118333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.