Evidence map›Paper›PMID 28695657›Full record

ArticleHLA2017

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.

E K K Henriksen, M K Viken, M Wittig, K Holm, T Folseraas, S Mucha, E Melum, J R Hov, K N Lazaridis, B D Juran and 20 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HLA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Association of Primary Sclerosing Cholangitis With HLA-C*07:02 in a Japanese Population.Liver international : official journal of the International Association for the Study of the Liver · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 18 institutions in 9 countries.

E K K HenriksenNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.ORCID 0000-0002-8105-6246
M K VikenK.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-3917-9269
M WittigInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
K HolmNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
T FolseraasNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
S MuchaInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
E MelumNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
J R HovNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
K N LazaridisCenter for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
B D JuranCenter for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
O ChazouillèresHôpital Saint-Antoine, Service d'Hépatologie, INSERM, UMR_S 938, CDR Saint-Antoine, and Sorbonne Universités, UPMC Univ Paris 06, Paris, France.
M FärkkiläHelsinki University and Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.
D N GotthardtDepartment of Gastroenterology, Infectious Diseases and Intoxications, University Hospital of Heidelberg, Heidelberg, Germany.
P InvernizziProgram for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
M CarboneProgram for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
G M HirschfieldCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
S M RushbrookThe Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk, UK.
E GoodeWellcome Trust Sanger Institute, Hinxton and Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
UK-PSC Consortium
C Y PonsioenDepartment of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.
R K WeersmaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
B EksteenSnyder Institute for Chronic Diseases, Division of Gastroenterology, University of Calgary, Calgary, Canada.
K K YimamDivision of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco, California.
S C GordonDivision of Gastroenterology and Hepatology, Henry Ford Health System, Detroit, Michigan.
D GoldbergDivision of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
L YuDepartment of Medicine, University of Washington, Seattle, Washington.
C L BowlusDivision of Gastroenterology and Hepatology, University of California Davis School of Medicine, Sacramento, California.
A FrankeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
B A LieK.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
T H KarlsenNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Oslo University Hospital · NOChristian-Albrechts-Universität zu Kiel · DEMayo Clinic · USUniversity of Milano-Bicocca · ITAmsterdam UMC Location University of Amsterdam · NLCalifornia Pacific Medical Center · USHeidelberg University · DEHenry Ford Health System · USHospital of the University of Pennsylvania · USInserm · FRNIHR Birmingham Liver Biomedical Research Unit · GBNorfolk and Norwich University Hospitals NHS Foundation Trust · GBUniversity Medical Center Groningen · NLUniversity of Calgary · CAUniversity of California, Davis · USUniversity of Cambridge · GBUniversity of Helsinki · FIUniversity of Washington · US

Funding

PSC Resource Of Genetic Risk, Environment and Synergy Studies (PROGRESS)R01DK084960 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2010 to 2014
$3.0M
NIDDK NIH HHS R01 DK084960
6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01-DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele.

Indexed as

Genetic Predisposition to DiseaseHaplotypesAllelesCholangitis, SclerosingEthnicityGene ExpressionGene FrequencyHLA-DQ beta-ChainsHLA-DRB1 ChainsHumansLinkage DisequilibriumScandinavian and Nordic CountriesWhite PeopleHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 Chainscausativehuman leukocyte antigenmulti-ethnicPSCtrans-ancestry

Identifiers

PMID28695657
PMCPMC7359736
OpenAlexW2734400862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.