ArticleHistochemistry and cell biology2017
Experimentally induced intrauterine growth restriction in rabbits leads to differential remodelling of left versus right ventricular myocardial microstructure.
Article in Histochemistry and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Correlation between echocardiographic and stereological parameters in rabbit models of myocardial infarction.Scientific reports · 2025Article
- Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling.bioRxiv : the preprint server for biology · 2025Article
- Scaling of quantitative cardiomyocyte properties in the left ventricle of different mammalian species.The Journal of experimental biology · 2025Article
- Assessing Coarctation of the Aorta With Fetal Heart Quantification Technology.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Pregnancy Complications and Feto-Maternal Monitoring in Rabbits.Veterinary sciences · 2023Review
- Review
- The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring.Biomedicines · 2022Article
- Review
- Sex differences and the effects of intrauterine hypoxia on growth and in vivo heart function of fetal guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches.Interface focus · 2019Review
- Structural coronary artery remodelling in the rabbit fetus as a result of intrauterine growth restriction.PloS one · 2019Article
- Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease.Journal of nutrition and metabolism · 2018Review
- Article
- Behaviour of the Foramen Ovale Flow in Fetuses with Intrauterine Growth Restriction.Obstetrics and gynecology international · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrauterine growth restriction (IUGR) is associated with foetal cardiac remodelling and dysfunction together with increased risk of cardiovascular disease in adulthood. Experimental data concerning effects of IUGR on cardiomyocyte and microvascularization anatomy are inconsistent and it is unknown whether both ventricles are similarly susceptible to in utero undersupply. Foetal IUGR was induced in pregnant rabbits at 25 days of gestation by selective ligation of uteroplacental vessels. Foetal echocardiography showed systolic and diastolic dysfunction of both ventricles and body and heart weight were significantly reduced in response to IUGR. Design-based stereology revealed a decrease in cardiomyocyte number in both ventricles which was only in the left ventricle accompanied by a significantly higher cardiomyocyte mean volume. The proportion of mono- and bi-nucleated cardiomyocytes was unaltered between the groups indicating a similar maturation status. The number and length of cardiac capillaries in IUGR offspring was diminished in left but not in right ventricles. Foetal left and right ventricles are differently affected by placental insufficiency. While cardiomyocyte numbers are diminished in both ventricles, hypertrophic remodelling of cardiomyocytes and alterations in microvascularization is rather a left ventricular adaptation to IUGR. These unequal structural changes may be related to loading and developmental differences of the left and right ventricles.
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Registered trials
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