Evidence map›Paper›PMID 28695321›Full record

ArticlePathology oncology research : POR2018

Angiogenesis and Lymphangiogenesis in the Adrenocortical Tumors.

Sofia S Pereira, Madalena M Costa, Susana G Guerreiro, Mariana P Monteiro, Duarte Pignatelli

Abstract read
PubMed Publisher
In one paragraph

Article in Pathology oncology research : POR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Adrenocortical Carcinoma Steroid Profiles:Frontiers in endocrinology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sofia S PereiraInstituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal.
Madalena M CostaClinical and Experimental Endocrinology, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto, Portugal.
Susana G GuerreiroInstituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal.
Mariana P MonteiroClinical and Experimental Endocrinology, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto, Portugal.
Duarte PignatelliInstituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal. dpignatelli@ipatimup.pt.
Universidade do Porto · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PT

Funding

Fundação para a Ciência e a Tecnologia SFRH/BD/89308/2012Fundação para a Ciência e a Tecnologia SFRH/BPD/111741/2015Fundação para a Ciência e a Tecnologia UID/BIM/04293/2013Fundação para a Ciência e a Tecnologia UID/Multi/00215/2013
6 · The paper itself

Abstract

Adrenocortical tumors (ACT) are common adrenal tumors. The majority of ACTs are non-functioning and benign, while adrenocortical carcinomas (ACC) are rare, usually very aggressive and often metastasized when first diagnosed. Our aim was to assess whether blood and lymph vessel density within ACTs correlate with the malignancy character or tumor functionality. For that, the microvascular distribution was evaluated by immunohistochemistry staining with D2-40 antibody, for lymph vessels and CD-31 antibody, for blood vessels, in ACCs (n = 15), adenomas with Cushing syndrome (n = 9) and non-functioning adenomas (n = 10). The percentage of stained area was quantified by computerized morphometric analysis. D2-40 expression was significantly lower in ACC as compared to adenomas with Cushing syndrome (p < 0.01) and correlated positively with the expression of the steroidogenic acute regulatory protein (StAR) (R

Indexed as

LymphangiogenesisAdenomaAdrenal Cortex NeoplasmsAdrenocortical CarcinomaBiomarkers, TumorHumansNeovascularization, PathologicPrognosisBiomarkers, TumorAdrenocortical carcinomaAdrenocortical tumorsAngiogenesisLymphangiogenesis

Identifiers

PMID28695321
OpenAlexW2732699349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.