Evidence map›Paper›PMID 28695297›Full record

ArticleVirchows Archiv : an international journal of pathology2017

Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.

Fabio Facchetti, Stefano Aldo Pileri, Luisa Lorenzi, Valentina Tabanelli, Lisa Rimsza, Stefania Pittaluga, Stephan Dirnhofer, Christiane Copie-Bergman, Laurence de Leval, Andreas Rosenwald and 2 more

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Meningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion.Virchows Archiv : an international journal of pathology · 2026
    Article
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  10. Article
  11. Histiocytic Sarcoma: A Review and Update.International journal of molecular sciences · 2025
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fabio FacchettiSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Spedali Civili, 25123, Brescia, Italy. fabio.facchetti@unibs.it.
Stefano Aldo PileriUnit of Hematopathology, European Institute of Oncology, 20141, Milan, Italy. stefano.pileri@ieo.it.
Luisa LorenziSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Spedali Civili, 25123, Brescia, Italy.
Valentina TabanelliUnit of Hematopathology, European Institute of Oncology, 20141, Milan, Italy.
Lisa RimszaDepartment of Laboratory Medicine and Pathology, The Mayo Clinic, Scottsdale, AZ, USA.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Stephan DirnhoferInstitute of Pathology and Genetics, University Hospital Basel, Basel, Switzerland.
Christiane Copie-BergmanDepartment of Pathology, Hopital Henri Mondor, INSERM U955, Université Paris-Est, Creteil, France.
Laurence de LevalInstitute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
Andreas RosenwaldInstitute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
Andrew WotherspoonDepartment of Histopathology, Royal Marsden Hospital, London and Sutton, UK.
Falko FendInstitute of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.

Funding

Associazione Italiana per la Ricerca sul Cancro 5x1000 10007 and IG 15762
6 · The paper itself

Abstract

Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs.Sixty-seven cases were submitted to the accessory cell and histiocytic neoplasms session at the European Association of Haematopathology/Society for Hematopathology workshop 2016 held in Basel, Switzerland. The cases included histiocytic sarcomas (HS), Langerhans cell tumors (LCT), Erdheim-Chester disease, interdigitating dendritic cell sarcomas (IDCS), indeterminate dendritic cell tumors (IND-DCT), follicular dendritic cell sarcomas, and blastic plasmacytoid dendritic cell neoplasms. Rosai-Dorfman disease and, more rare, conditions such as ALK-positive histiocytosis were also submitted. These cases illustrated classical and unexpected features at morphological, phenotypical, and molecular levels, providing a valuable compendium for pathologists confronting with these tumors.The paper summarizes the most notable features of every single group of diseases, with comments about the most challenging issues, in the attempt to provide practical indications for their recognition.

Indexed as

Dendritic CellsFemaleHistiocytic SarcomaHumansMaleDendritic cellsHistiocytesNeoplasmsTumors

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.