ArticleAmerican journal of clinical and experimental immunology2017
The chemokine CCL28 is elevated in the serum of patients with celiac disease and decreased after treatment.
Article in American journal of clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation.Molecular medicine reports · 2022Observational
- Incidence of Cancer in Patients with Irritable Bowl Syndrome.Journal of clinical medicine · 2021Article
- Expression of Chemokine CCL28 in Ulcerative Colitis Patients.Gut and liver · 2021Article
- The CCL28 levels are elevated in the serum of patients with irritable bowel syndrome and associated with the clinical symptoms.American journal of clinical and experimental immunology · 2021Article
- Article
- Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence show that many inflammatory cytokines are involved in pathophysiology of celiac disease (CD). CCL28 known as mucosa associate epithelial chemokine (MEC) is produced by mucosa and chemoattracts IgA-producing B cells into the mucosa. However, its levels in patients with CD have not yet been elucidated. CCL28 levels and anti-tTTG (IgA) were detected in the serum of 28 new cases of CD, 32 cases of treated patents and 32 normal individuals by Elisa. Moreover, the effect of gluten on intestinal cells, Caco-2, was examined by RT-PCR. Our data show that (i) the levels of CCL28 is significantly higher in patients with CD than normal individuals, (ii) CCL28 levels is reduced in patients with CD who had gluten-free diets. Accordingly, we observed that CCL28 expression is upregulated in a dose-dependent manner when the Caco-2 cells were cultured in the presence of gluten. In conclusion, gluten enhances CCL28 expression and that CCL28 could be a novel biomarker for diagnosis and following up the patients with CD. However, further investigation in a larger number of patients is required.
Indexed as
Identifiers
28695058PMC5498852W2954816865What OpenQuestion holds
Registered trials
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