ArticleChemical science2015
Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Water-Derived Radical Species Initiate Six-Electron Oxidation of Cyclic Ketones in Microdroplets.Angewandte Chemie (International ed. in English) · 2026Article
- Accelerated Chemistry in Microdroplets.Accounts of chemical research · 2026Article
- DFT and Mass Spectrometry Study of (-)ESI-Induced Fragmentation of the Highly Toxic Rodenticide Tetramethylenedisulfotetramine.ACS omega · 2026Article
- Dark Reactions in Microdroplets Explain Widespread Artifacts in Metabolomic Profiling.ACS measurement science au · 2026Article
- Enhancement of Esterification Reaction Rates in Solvent-Free Aerosol Droplets.Journal of the American Chemical Society · 2026Article
- Mechanisms of ionization and of chemical reactions in charged microdroplets.Chemical science · 2025Review
- Interfacial electromigration for accelerated reactions.Analytica chimica acta · 2025Article
- Dissolved Oxygen Redox as the Source of Hydrogen Peroxide and Hydroxyl Radical in Sonicated Emulsive Water Microdroplets.Journal of the American Chemical Society · 2025Article
- Oxazolone mediated peptide chain extension and homochirality in aqueous microdroplets.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hammett correlation in competition experiments in dissociation of ionised substituted benzophenones and dibenzylideneacetones.European journal of mass spectrometry (Chichester, England) · 2023Article
- pH jump kinetics in colliding microdroplets: accelerated synthesis of azamonardine from dopamine and resorcinol.Chemical science · 2023Article
- Reaction nanoscopy of ion emission from sub-wavelength propanediol droplets.Nanophotonics (Berlin, Germany) · 2023Article
- Abiotic microcompartments form when neighbouring droplets fuse: an electrochemiluminescence investigation.Chemical science · 2023Article
- Spatial reorganization of analytes in charged aqueous microdroplets.Chemical science · 2022Article
- The driving effects of common atmospheric molecules for formation of prenucleation clusters: the case of sulfuric acid, formic acid, nitric acid, ammonia, and dimethyl amine.Environmental science: atmospheres · 2022Article
- Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair.Angewandte Chemie (International ed. in English) · 2022Article
- Oxidation of Cysteine by Electrogenerated Hexacyanoferrate(III) in Microliter Droplets.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Investigation of Tryptic Protein Digestion in Microdroplets and in Bulk Solution.Journal of the American Society for Mass Spectrometry · 2022Article
- Spontaneous Water Radical Cation Oxidation at Double Bonds in Microdroplets.Frontiers in chemistry · 2022Article
- Accelerated synthesis of energetic precursor cage compounds using confined volume systems.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex chemical reactions can occur in electrosprayed droplets on the millisecond time scale. The Hantzsch synthesis of 1,4-dihydropyridines was studied in this way using on-line mass spectral analysis to optimize conditions and characterize the product mixture. Changing the distance between the nanospray source and the MS inlet allowed exploration of reaction progress as a function of droplet time-of-flight. Desolvation of the charged microdroplets is associated with transformation from starting material to intermediates and eventually to product as the distance is increased. Results of the on-line experiments require a termination step that discontinuously completes the desolvation process and allows the generated gaseous ions to be used to characterize the state of the system at a particular time. The intermediates seen correspond to those known to occur in the bulk solution-phase reaction. Off-line collection of the sprayed reaction mixture allowed the recovery of 250 mg h
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.