Evidence map›Paper›PMID 28694932›Full record

ArticleComputational and structural biotechnology journal2017

Nuclear Magnetic Resonance (NMR) Study for the Detection and Quantitation of Cholesterol in HSV529 Therapeutic Vaccine Candidate.

Rahima Khatun, Howard Hunter, Webster Magcalas, Yi Sheng, Bruce Carpick, Marina Kirkitadze

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. NMR-Based Stable Isotope Tracing of Cancer Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Simple and Cost-effective Enzymatic Detection of Cholesterol Using Flow Injection Analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020
    Article
  8. Spinogenesis and Synaptogenesis Effects of the Red SeaweedPreventive nutrition and food science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rahima KhatunDepartment of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada.
Howard HunterDepartment of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada.
Webster MagcalasAnalytical Research & Development, Sanofi Pasteur Ltd., 1755 Steeles Avenue West, Toronto, Ontario, Canada.
Yi ShengDepartment of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada.
Bruce CarpickAnalytical Research & Development, Sanofi Pasteur Ltd., 1755 Steeles Avenue West, Toronto, Ontario, Canada.
Marina KirkitadzeAnalytical Research & Development, Sanofi Pasteur Ltd., 1755 Steeles Avenue West, Toronto, Ontario, Canada.
Sanofi (Canada) · CAYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related impurity in the replication-deficient Herpes Simplex Virus (HSV) type 2 candidate vaccine HSV529. Three signature peaks from the 1D

Indexed as

Growth supplementHerpes simplex virus type 2 (HSV-2)LOD and LOQNMRResidualsTLCViral vaccine

Identifiers

PMID28694932
PMCPMC5484764
OpenAlexW2548099147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.