Evidence map›Paper›PMID 28694920›Full record

ReviewInternational journal of physiology, pathophysiology and pharmacology2017

Role of microglia in methamphetamine-induced neurotoxicity.

Enquan Xu, Jianuo Liu, Han Liu, Xiaobei Wang, Huangui Xiong

Open access · greenAbstract readReview
In one paragraph

Review in International journal of physiology, pathophysiology and pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  15. Intraperitoneal injection of buprenorphine on anxiety-like behavior and alteration in expression ofVeterinary research forum : an international quarterly journal · 2022
    Article
  16. Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Enquan XuNeurophysiology Laboratory, Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha 68198-5880, NE, USA.
Jianuo LiuNeurophysiology Laboratory, Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha 68198-5880, NE, USA.
Han LiuNeurophysiology Laboratory, Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha 68198-5880, NE, USA.
Xiaobei WangCollege of Pharmacy, University of Nebraska Medical Center Omaha 68198-6125, NE, USA.
Huangui XiongNeurophysiology Laboratory, Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha 68198-5880, NE, USA.
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

Microglial ion channels and HIV-1-associated dementiaR01NS077873 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIONG, HUANGUI HANK · 2012 to 2016
$1.8M
NINDS NIH HHS R01 NS077873
6 · The paper itself

Abstract

Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury. However, the mechanisms underlying Meth-induced microglial activation remain to be determined. In this review, we attempt to address the effects of Meth on human immunodeficiency virus (HIV)-associated microglia activation both

Indexed as

Drug abusemethamphetaminemicroglianeuroinflammationneurotoxicity

Identifiers

PMID28694920
PMCPMC5498881
OpenAlexW2755291908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.