Evidence map›Paper›PMID 28694834›Full record

ArticleImmunity & ageing : I & A2017

Influenza vaccine response in community-dwelling German prefrail and frail individuals.

Jürgen M Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub, Karine Vidal

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02262091 (Strengthening Immunity of Prefrail and Frail Elderly by WGP), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02262091 nacompletednot on this map

Strengthening Immunity of Prefrail and Frail Elderly by WGP

TypeinterventionalSponsorSociété des Produits Nestlé (SPN)Ran2014 to 2014Enrolled150ConditionsElderly PeopleArmsFood fibers, Maltodextrin, Influenza vaccine (incl. criterion)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Observational
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jürgen M BauerDepartment of Geriatric Medicine, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Antonio De CastroNestlé Research Center, Route du Jorat 57, 1000 Lausanne, Switzerland.
Nabil BoscoNestlé Research Center, Route du Jorat 57, 1000 Lausanne, Switzerland.
Celine RomagnyNestlé Research Center, Route du Jorat 57, 1000 Lausanne, Switzerland.
Rebecca DiekmannDepartment of Geriatric Medicine, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Jalil BenyacoubNestlé Research Center, Route du Jorat 57, 1000 Lausanne, Switzerland.
Karine VidalNestlé Research Center, Route du Jorat 57, 1000 Lausanne, Switzerland.
Nestlé (Switzerland) · CHCarl von Ossietzky Universität Oldenburg · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest of morbidity and mortality due to infection. Recently, significantly reduced anti-influenza antibody titers and increased rates of influenza infection after vaccination were reported in community-dwelling American frail older adults. The aim of our study was to further assess the relative impact of frailty and of each individual Fried frailty criterion on influenza vaccine response. Prefrail and frail community-dwelling German persons aged ≥70 years were recruited for a nutritional randomized double-blind placebo-controlled clinical trial conducted during the 2014-2015 influenza season. Herein, we present a sub-analysis study of the placebo group to compare 76 prefrail and frail participants.

resultsPrevious seasonal influenza vaccination rate was relatively high (77.6%) in the 76 volunteers aged from 70 to 93 years. Of these participants, 65.8% were diagnosed as prefrail and 34.2% as frail according to the Fried frailty criteria. In both prefrail and frail groups, elevated levels of pre-vaccination seroprotection were observed to all vaccine strains (H1N1: 54% and 32%, H3N2: 60% and 72%, B: 10% and 16%). Post-vaccination, similar increases in haemagglutination-inhibiting antibody titers were observed for the three vaccine strains in both prefrail and frail groups. No significant difference in geometric mean titer (GMT) ratios and in rates of seroconversion or seroprotection were observed between prefrail and frail groups. Regarding the five Fried frailty criteria, only participants with low physical activity had significantly lower GMT to the strains H3N2 (55.4 vs 103.7,

conclusionsInfluenza vaccine response was not significantly affected by the frail phenotype, as defined by Fried frailty criteria, in community-dwelling German individuals. However, low physical activity may be a relevant predictor of lower serological response in vaccinated older individuals.

trial registrationClinicaltrials.gov NCT02262091 (October 8, 2013).

Indexed as

ElderlyFrailtyInfluenzaVaccination

Identifiers

PMID28694834
PMCPMC5501346
OpenAlexW2724622108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.