ArticleFrontiers in neuroanatomy2017
Loud Noise Exposure Produces DNA, Neurotransmitter and Morphological Damage within Specific Brain Areas.
Article in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Psychophysiological Implications of Soundscape: A Systematic Review of Empirical Literature and a Research Agenda.International journal of environmental research and public health · 2019Pooled it
- Short-Term Exposure to Noise and Ethanol Intake Induces Changes in Aminoacidergic Neurotransmisson and Thioredoxin-1 Levels in the Cerebellum and Hippocampus of Adolescent Male Wistar Rats.Cerebellum (London, England) · 2026Article
- Chronic Loud Noise-Biochemical and Ultrastructural Alterations in Auditory and Limbic Regions of the Rat Brain.BioMed research international · 2026Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Toxicopathological changes induced by combined exposure to noise and toluene in New Zealand White rabbits.Arhiv za higijenu rada i toksikologiju · 2022Article
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
- Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats.Neurochemical research · 2020Article
- The use of nonhuman primates in studies of noise injury and treatment.The Journal of the Acoustical Society of America · 2019Review
- A New Approach to Treating Neurodegenerative Otologic Disorders.BioResearch open access · 2018Article
- Sound-stress-induced altered nociceptive behaviors are associated with increased spinal CRFR2 gene expression in a rat model of burn injury.Journal of pain research · 2017Article
- Electron microscopy demonstrating noise exposure alters synaptic vesicle size in the inferior colliculus of cat.Noise & healthArticle
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Authors and funding
13 authors.
Funding
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Abstract
Exposure to loud noise is a major environmental threat to public health. Loud noise exposure, apart from affecting the inner ear, is deleterious for cardiovascular, endocrine and nervous systems and it is associated with neuropsychiatric disorders. In this study we investigated DNA, neurotransmitters and immune-histochemical alterations induced by exposure to loud noise in three major brain areas (cerebellum, hippocampus, striatum) of Wistar rats. Rats were exposed to loud noise (100 dBA) for 12 h. The effects of noise on DNA integrity in all three brain areas were evaluated by using Comet assay. In parallel studies, brain monoamine levels and morphology of nigrostriatal pathways, hippocampus and cerebellum were analyzed at different time intervals (24 h and 7 days) after noise exposure. Loud noise produced a sudden increase in DNA damage in all the brain areas under investigation. Monoamine levels detected at 7 days following exposure were differently affected depending on the specific brain area. Namely, striatal but not hippocampal dopamine (DA) significantly decreased, whereas hippocampal and cerebellar noradrenaline (NA) was significantly reduced. This is in line with pathological findings within striatum and hippocampus consisting of a decrease in striatal tyrosine hydroxylase (TH) combined with increased Bax and glial fibrillary acidic protein (GFAP). Loud noise exposure lasting 12 h causes immediate DNA, and long-lasting neurotransmitter and immune-histochemical alterations within specific brain areas of the rat. These alterations may suggest an anatomical and functional link to explain the neurobiology of diseases which prevail in human subjects exposed to environmental noise.
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