The androgen receptor plays different roles in macrophage-induced proliferation in prostate stromal cells between transitional and peripheral zones of benign prostatic hypertrophy.

Dongliang Xu, Xingjie Wang, Chenyi Jiang, Yuan Ruan, Shujie Xia, Xiaohai Wang

Open access · greenAbstract read

In one paragraph

Article in EXCLI journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

10citing papers in PubMed, 1 pooled it

1.6field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

Is COVID-19 a risk factor for progression of benign prostatic hyperplasia and exacerbation of its related symptoms?: a systematic review.Prostate cancer and prostatic diseases · 2022
Pooled it
Phytochemical Profiling of the Halophyte Artemisia fukudo Makino and Its In Vitro Effects on Androgen-Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia.ChemistryOpen · 2026
Article
The Effects of Caloric Restriction on Inflammatory Targets in the Prostates of Aged Rats.International journal of molecular sciences · 2024
Article
A Novel Insight into the Immune-Related Interaction of Inflammatory Cytokines in Benign Prostatic Hyperplasia.Journal of clinical medicine · 2023
Review
Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review.Life (Basel, Switzerland) · 2022
Review
Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia.Antioxidants (Basel, Switzerland) · 2021
Article
The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review.Asian journal of urology · 2020
Review
Botanical preparation HX109 inhibits macrophage-mediated activation of prostate epithelial cells through the CCL4-STAT3 pathway: implication for the mechanism underlying HX109 suppression of prostate hyperplasia.Heliyon · 2020
Article
Protective effects of combination of Stauntonia hexaphylla and Cornus officinalis on testosterone-induced benign prostatic hyperplasia through inhibition of 5α- reductase type 2 and induced cell apoptosis.PloS one · 2020
Article
Aconiti Lateralis Radix Preparata, the Dried Root ofEvidence-based complementary and alternative medicine : eCAM · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dongliang XuDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

Xingjie WangDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

Chenyi JiangDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

Yuan RuanDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

Shujie XiaDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

Xiaohai WangDepartment of Urology, Shanghai General Hospital, Address: No. 100 Haining Road, Hongkou district, Post code: 200080, Shanghai, China; Telephone: +86 13916482122 (Wang); Telephone: +86 15301655577 (Xia).

TCL (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate

Indexed as

androgen receptorbenign prostatic hyperplasiamacrophagestromal celltransitional zone

Identifiers

PMID28694768

DOI10.17179/excli2017-335

PMCPMC5500834

OpenAlexW2770277733

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.