ArticleEXCLI journal2017
Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats.
Article in EXCLI journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Chronic REM Sleep Deprivation Induces Metabolic and Neurotoxic Alterations Associated with Affective and Cognitive Deficit in Male Wistar Rats: Involvement of HPA Axis, Cholinergic, Inflammatory, and Oxidative Stress Pathways.Neurochemical research · 2026Article
- Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities.CNS & neurological disorders drug targets · 2024Review
- Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases.Frontiers in neuroscience · 2024Article
- Curcumin mitigates the sleep-deprivation impacts on rat hypothalamic paraventricular nucleus.IBRO neuroscience reports · 2023Article
- Overexpression ofNeural regeneration research · 2023Article
- The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models.Clocks & sleep · 2023Review
- Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.Molecular neurodegeneration · 2023Review
- Sleep deprivation induces structural changes in the adult rat testis: The protective effects of olive oil.Clinical and experimental reproductive medicine · 2023Article
- Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brainThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- A New Perspective on the Treatment of Alzheimer's Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?Oxidative medicine and cellular longevity · 2022Review
- The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Alzheimer's Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link.Cells · 2021Review
- Curcumin prevents neuronal loss and structural changes in the superior cervical (sympathetic) ganglion induced by chronic sleep deprivation, in the rat model.Biological research · 2020Article
- Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models.Neurobiology of disease · 2020Review
- Long-term effects of curcumin in the non-human primate brain.Brain research bulletin · 2018Article
- Does curcumin have an effect on sleep duration in metabolic syndrome patients?Avicenna journal of phytomedicineArticle
- Curcumin Effects on Memory Impairment and Restoration of Irregular Neuronal Distribution in the Hippocampal CA1 Region After Global Cerebral Ischemia in Male Rats.Basic and clinical neuroscienceArticle
- Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep Deprivation (SD) is known to result in a range of neurological consequences in chronically-afflicted subjects. Curcumin, a natural substance, has neuroprotective properties. This study aimed to evaluate the effects of curcumin on the medial Prefrontal Cortex (mPFC) of SD rats. Male rats were arbitrarily assigned to nine groups, including control, curcumin (100 mg/kg/day), olive oil, SD, SD+curcumin, SD+olive oil, grid, grid+curcumin, and grid+olive oil groups. SD was induced by a multiplatform box containing water. After a period of 21 days, the learning and memory of the rats were tested in an eight-arm radial maze. Afterwards, their brains were evaluated using stereological methods. Concomitant treatment of curcumin during SD caused fewer errors during evaluation of the working and reference memory errors in the acquisition and retention phases. The overall volume of the mPFC, Infralimbic Cortex (ILC), Prelimbic Cortex (PLC), Anterior Cingulate Cortex (ACC) and the total number of neurons and glial cells reduced by 20 %-40 % on average in the SD animals in comparison to the control group. This indicated atrophic changes and cell loss in these areas (p < 0.01). The dendrites' length and the number of spines per dendrite also reduced by 35 %-55 % in the SD rats compared to the ones in the control group (p < 0.01). Yet, treatment of the SD animals with curcumin prevented the atrophic changes of the mPFC, cell loss, and dendritic changes (p < 0.05). SD induced structural changes in the mPFC and memory impairment in the rats. However, curcumin could protect their PFC.
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