Observational studyInternational journal of chronic obstructive pulmonary disease2017
Prevalence and characteristics of asthma-COPD overlap syndrome identified by a stepwise approach.
Observational study in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis.The European respiratory journal · 2022Pooled it
- Clinical Indicators for Asthma-COPD Overlap: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2022Pooled it
- Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria.Journal of pharmaceutical policy and practice · 2026Review
- The Perception of Asthma, Chronic Obstructive Pulmonary Disease, Asthma and Chronic Obstructive Pulmonary Disease Overlap, and Cough Variant Asthma: A Retrospective Observational Study.Internal medicine (Tokyo, Japan) · 2025Observational
- Retrospective Cohort Study of Elderly Users of Single- or Multiple-Inhaler Triple Therapy for the Treatment of Asthma in the USA.Pulmonary therapy · 2025Article
- Nontuberculous mycobacterial pulmonary disease added burden to COPD and bronchiectasis in Japan.ERJ open research · 2024Article
- Epidemiological characteristics of asthma-COPD overlap, its association with all-cause mortality, and the mediating role of depressive symptoms: evidence from NHANES 2005-2018.BMC public health · 2024Article
- COPD Patients with Asthma Features in Vietnam: Prevalence and Suitability for Personalized Medicine.Journal of personalized medicine · 2023Article
- Efficacy and safety of once-daily single-inhaler triple therapy for mild-to-moderate chronic obstructive pulmonary disease: a study protocol for a randomised and interventional study.BMJ open respiratory research · 2023Article
- Undiagnosed Asthma-COPD overlap among patients diagnosed as Asthma and COPD in a referral hospital, India.Heliyon · 2023Article
- Phenotype and management of chronic obstructive pulmonary disease patients in general population in China: a nationally cross-sectional study.NPJ primary care respiratory medicine · 2021Article
- Asthma and Chronic Obstructive Pulmonary Disease Overlap According to the Japanese Respiratory Society Diagnostic Criteria: The Prospective, Observational ACO Japan Cohort Study.Advances in therapy · 2021Observational
- Dynamic Urinary Proteome Changes in Ovalbumin-Induced Asthma Mouse Model Using Data-Independent Acquisition Proteomics.Journal of asthma and allergy · 2021Article
- Clinical Characteristics and Changes of Clinical Features in Patients with Asthma-COPD Overlap in Korea according to Different Diagnostic Criteria.Tuberculosis and respiratory diseases · 2020Article
- Impact of Clinical Factors on Generic and Disease-Specific Quality of Life in COPD and Asthma-COPD Overlap with Exacerbations.Pulmonary medicine · 2020Article
- Clinical Characteristics and Outcomes of Patients with Asthma-COPD Overlap in Japanese Patients with COPD.International journal of chronic obstructive pulmonary disease · 2020Observational
- Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- [Correlation between expressions of myeloperoxidase and eosinophil cationic protein in sputum and clinical features of asthma-chronic obstructive pulmonary disease overlap].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.International journal of chronic obstructive pulmonary disease · 2018Article
- Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThere is increasing recognition of asthma-COPD overlap syndrome (ACOS), which shares some features of both asthma and COPD; however, the prevalence and characteristics of ACOS are not well understood. The aim of this study was to investigate the prevalence of ACOS among patients with COPD and its characteristics using a stepwise approach as stated in the recent report of the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD).
methodsThis multicenter, cross-sectional, observational study enrolled outpatients who were receiving medical treatment for COPD. Clinical data, including spirometry results, were retrieved from medical records. For symptom assessment, patients were asked to complete the Clinical COPD questionnaire and the modified British Medical Research Council questionnaire.
resultsOf the 1,008 patients analyzed, 167 (16.6%) had syndromic features of ACOS. Of the total number of patients, 93 and 42 (9.2% and 4.2%) also had a predefined clinical variability of ≥12%/≥200 mL and ≥12%/≥400 mL in forced expiratory volume in 1 second (FEV
conclusionUsing a stepwise approach, as stated in the GINA/GOLD report, the proportions of patients identified as having ACOS were found to be 9.2% and 4.2% (depending on the FEV
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