Evidence map›Paper›PMID 28694689›Full record

ArticleDrug design, development and therapy2017

Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3'

Jingrun Chen, Junjie Liu, Dongxiao Cui, Chaoqun Yan, Liqiang Meng, Liqian Sun, Shurong Ban, Rui Ge, Taigang Liang, Qingshan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingrun ChenLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Junjie LiuLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Dongxiao CuiLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Chaoqun YanLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Liqiang MengLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Liqian SunLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Shurong BanLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Rui GeLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Taigang LiangLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.
Qingshan LiLaboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3'

Indexed as

Antineoplastic Agents, PhytogenicApoptosisCaspasesCell Line, TumorCoumarinsDrug Screening Assays, AntitumorEnzyme ActivationHumansMagnetic Resonance SpectroscopyMembrane Potential, MitochondrialSignal TransductionStructure-Activity RelationshipTandem Mass SpectrometryTetrazolium SaltsThiazolesAntineoplastic Agents, PhytogenicCaspasesCoumarinskhellactoneTetrazolium SaltsThiazolesthiazolyl blue4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactonesapoptosiscytotoxic activitysynthesis

Identifiers

PMID28694689
PMCPMC5491701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.