Observational studyWorld journal of gastroenterology2017
Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease.
Observational study in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive value of blood concentration of biologics on endoscopic inactivity in inflammatory bowel disease: A systematic review.World journal of gastroenterology · 2021Pooled it
- Strategies to Optimize Anti-tumor Necrosis Factor Therapy for Perianal Fistulizing Crohn's Disease: A Systematic Review.Digestive diseases and sciences · 2019Pooled it
- Comprehensive Imaging Evaluation and Staging of Crohn's Disease: When and Why to Use Intestinal Ultrasound, MRE, or CTE: Current Guidelines and Future Directions.Diagnostics (Basel, Switzerland) · 2026Review
- Sequence-robust MRI asymmetry measures for the detection of anoperineal lesions in Crohn's disease on axial pelvic MRI scans.PloS one · 2026Article
- Imaging in perianal fistulising Crohn's disease: A practical guide for the gastroenterologist.World journal of gastroenterology · 2025Review
- Total fistula volume predicts surgical outcomes in complex perianal fistulizing Crohn's disease following fistula-tract laser closure: a single-center retrospective study.Techniques in coloproctology · 2025Article
- Which magnetic resonance imaging feature is associated with treatment response in perianal fistulizing Crohn's disease?Abdominal radiology (New York) · 2024Article
- Clinical and magnetic resonance imaging spectrum of complex perianal fistulizing Crohn's disease: A cohort study from northern India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Prognostic factors for the efficacy of infliximab in patients with luminal fistulizing Crohn's disease.BMC gastroenterology · 2023Article
- Relationship between clinical remission of perianal fistulas in Crohn's disease and serum adalimumab concentrations: A multi-center cross-sectional study.World journal of gastroenterology · 2022Article
- Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn's Disease: Rationale, Clinical Results and Perspectives.International journal of molecular sciences · 2021Review
- Treatment Strategy for Perianal Fistulas in Crohn Disease Patients: The Surgeon's Point of View.Annals of coloproctology · 2021Review
- Long-term outcomes of perianal fistulizing Crohn's disease in the biologic era.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta-analysis.JGH open : an open access journal of gastroenterology and hepatology · 2020Review
- Optimized timing of using infliximab in perianal fistulizing Crohn's disease.World journal of gastroenterology · 2020Review
- Evaluating the effectiveness of infliximab on perianal fistulizing Crohn's disease by magnetic resonance imaging.Gastroenterology report · 2019Article
- Defining and predicting deep remission in patients with perianal fistulizing Crohn's disease on anti-tumor necrosis factor therapy.World journal of gastroenterology · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the imaging course of Crohn's disease (CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep remission.
methodsAll patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging (MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment (remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs (T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.
resultsForty-nine consecutive patients (31 females and 18 males) were included. They ranged in age from 14-70 years (mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI (T2 hyperintensity,
conclusionDeep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission.
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