Evidence map›Paper›PMID 28694567›Full record

ArticleJournal of Indian Association of Pediatric Surgeons

Immunohistochemistry in Ureteropelvic Junction Obstruction and Its Correlation to Postoperative Outcome.

Anusiri Inugala, Ramesh Kota Reddy, Bhuvaneshwar Nadipalli Rao, Sreenivas P Reddy, Radhika Othuluru, Lavanya Kanniyan, Nagarjuna Kumbha, Srinivas Srirampur

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Indian Association of Pediatric Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. New Horizon in Understanding of Pediatric Surgical Diseases.Journal of Indian Association of Pediatric Surgeons
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Factors Accountable for Unabated Obstruction Following Pyeloplasty.Journal of Indian Association of Pediatric Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anusiri InugalaDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Ramesh Kota ReddyDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Bhuvaneshwar Nadipalli RaoDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Sreenivas P ReddyDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Radhika OthuluruDepartment of Pathology, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Lavanya KanniyanDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Nagarjuna KumbhaDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Srinivas SrirampurDepartment of Pediatric Surgery, Niloufer Institute of Women and Child Health, Hyderabad, Telangana, India.
Niloufer Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the correlation between the status of interstitial cells of Cajal (ICC) in ureteropelvic junction (UPJ) and the resected ureteric margin and the postoperative outcome of Anderson-Hynes pyeloplasty in UPJ obstruction (UPJO) and to compare the ICC in the UPJ and the resected margin of the normal ureter. MATERIALS AND

methodsAn observational study was conducted over a period of 2 years at the Department of Pediatric Surgery at Niloufer Institute of Women and Child Health. Children with intrinsic UPJO who underwent Anderson-Hynes dismembered pyeloplasty were included in the study. Six months postoperatively, the patients were divided into two groups based on diuretic isotopic renogram using technetium-99m-labeled diethylene triaminepentaacetic acid. Group 1 comprised patients with good surgical outcome. Group 2 comprised patients with a poor outcome. The histologic specimens were evaluated for ICC, and the immunohistochemical findings were correlated with the outcome.

resultsTwenty-five patients were included in this study (19 male and 6 female). Seventy-six percent of patients were under the age of 1 year. Group 1 had 23 cases and Group 2 had 2 cases. Out of the two patients with a poor outcome, one had negative grading at the UPJ and one had positive grading. Both these patients had a negative grading at the lower resected margins. More number of patients (24%) had +++ grading at the lower resected margin when compared to the UPJ (8%).

conclusionThis is the first study which correlates the status of ICC in UPJ with the outcome of pyeloplasty in pediatric patients. Both the cases with bad outcome had no ICC at the lower margin of the resected specimen and one case had no ICC at the UPJ. There is a statistically significant difference (

Indexed as

Anderson-Hynes pyeloplastyimmunohistochemistryinterstitial cells of Cajalureteropelvic junctionureteropelvic junction obstruction

Identifiers

PMID28694567
PMCPMC5473296
OpenAlexW2624128165

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.