ArticleScientific reports2017
Within-host Evolution of Segments Ratio for the Tripartite Genome of Alfalfa Mosaic Virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Small impact of the host plant physiological state on the genome formula of a nanovirus.PLoS pathogens · 2026Article
- A Single Amino Acid in Cucumber Mosaic Virus Determines Systemic Infection in Legumes: Species-Specific Differences in Key Residue Locations.International journal of molecular sciences · 2025Article
- Living Together Apart: Quantitative Perspectives on the Costs and Benefits of a Multipartite Genome Organization in Viruses.Viruses · 2025Article
- Relative frequency dynamics and loading of beet necrotic yellow vein virus genomic RNAs during the acquisition by its vectorJournal of virology · 2025Article
- Aspects of the lifestyle of multipartite viruses apply to monopartite segmented and perhaps nonsegmented viruses.Npj viruses · 2024Review
- Replication-independent change in the frequencies of distinct genome segments of a multipartite virus during its transit within aphid vectors.Microbiology spectrum · 2024Article
- Robust Approaches to the Quantitative Analysis of Genome Formula Variation in Multipartite and Segmented Viruses.Viruses · 2024Article
- Conserved untranslated regions of multipartite viruses: Natural markers of novel viral genomic components and tags of viral evolution.Virus evolution · 2024Article
- The genome formula of a multipartite virus is regulated both at the individual segment and the segment group levels.PLoS pathogens · 2024Article
- Constant ratio between the genomic components of bipartite begomoviruses during infection and transmission.Virology journal · 2023Article
- Genome segment ratios change during whitefly transmission of two bipartite cassava mosaic begomoviruses.Scientific reports · 2023Article
- Evaluation of sequencing and PCR-based methods for the quantification of the viral genome formula.Virus research · 2023Article
- A New Perspective on the Co-Transmission of Plant Pathogens by Hemipterans.Microorganisms · 2023Review
- Determinants of Virus Variation, Evolution, and Host Adaptation.Pathogens (Basel, Switzerland) · 2022Review
- Nonconcomitant host-to-host transmission of multipartite virus genome segments may lead to complete genome reconstitution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of an Alphasatellite on the Life Cycle of the NanovirusJournal of virology · 2022Article
- Evolutionary history and global spatiotemporal pattern of alfalfa mosaic virus.Frontiers in microbiology · 2022Article
- Gene copy number variations at the within-host population level modulate gene expression in a multipartite virus.Virus evolution · 2022Article
- Ever-increasing viral diversity associated with the red imported fire ant Solenopsis invicta (Formicidae: Hymenoptera).Virology journal · 2021Article
- Alfalfa mosaic virus nanoparticles-basedNanomedicine (London, England) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence of multipartite viruses is an intriguing mystery in evolutionary virology. Several hypotheses suggest benefits that should outweigh the costs of a reduced transmission efficiency and of segregation of coadapted genes associated with encapsidating each segment into a different particle. Advantages range from increasing genome size despite high mutation rates, faster replication, more efficient selection resulting from reassortment during mixed infections, better regulation of gene expression, or enhanced virion stability and cell-to-cell movement. However, support for these hypotheses is scarce. Here we report experiments testing whether an evolutionary stable equilibrium exists for the three genomic RNAs of Alfalfa mosaic virus (AMV). Starting infections with different segment combinations, we found that the relative abundance of each segment evolves towards a constant ratio. Population genetic analyses show that the segment ratio at this equilibrium is determined by frequency-dependent selection. Replication of RNAs 1 and 2 was coupled and collaborative, whereas the replication of RNA 3 interfered with the replication of the other two. We found that the equilibrium solution is slightly different for the total amounts of RNA produced and encapsidated, suggesting that competition exists between all RNAs during encapsidation. Finally, we found that the observed equilibrium appears to be host-species dependent.
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