ArticleScientific reports2017
High Frequency Components of Hemodynamic Shear Stress Profiles are a Major Determinant of Shear-Mediated Platelet Activation in Therapeutic Blood Recirculating Devices.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03255928 (Analysis of the Platelet Activity State in Patients Implanted With Ventricular Assist Device), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of the Platelet Activity State in Patients Implanted With Ventricular Assist Device (VAD)
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Protruding Objects in the Membrane Lung Outlet May Increase Thrombogenicity: Fluid Dynamical Insights.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Morphotype-based risk stratification in patients with patent foramen ovale using computational fluid dynamics.Scientific reports · 2025Article
- Vibro-Acoustic Platelet Activation: An Additive Mechanism of Prothrombosis with Applicability to Snoring and Obstructive Sleep Apnea.Bioengineering (Basel, Switzerland) · 2023Article
- A Clinical-Scale Microfluidic Respiratory Assist Device with 3D Branching Vascular Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A prestressed intracellular biomechanical model for the platelet to capture the disc-to-sphere morphological change from resting to activated state.International journal of computational methods · 2022Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?Frontiers in cardiovascular medicine · 2022Article
- Clinical predictors and sequelae of computed tomography defined leaflet thrombosis following transcatheter aortic valve replacement at medium-term follow-up.Heart and vessels · 2021Article
- Shear-mediated platelet activation in the free flow II: Evolving mechanobiological mechanisms reveal an identifiable signature of activation and a bi-directional platelet dyscrasia with thrombotic and bleeding features.Journal of biomechanics · 2021Review
- Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.Journal of biomechanics · 2021Article
- [Application of hemodynamic optimization in the design of artificial heart].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Platelet Activation via Shear Stress Exposure Induces a Differing Pattern of Biomarkers of Activation versus Biochemical Agonists.Thrombosis and haemostasis · 2020Article
- Platelet activation via dynamic conformational changes of von Willebrand factor under shear.PloS one · 2020Article
- Modeling sensitivity and uncertainties in platelet activation models applied on centrifugal pumps for extracorporeal life support.Scientific reports · 2019Article
- Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Article
- Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation-Initial validation versus the standardized hemodynamic shearing device.Biomicrofluidics · 2018Article
- Routine clinical anti-platelet agents have limited efficacy in modulating hypershear-mediated platelet activation associated with mechanical circulatory support.Thrombosis research · 2018Article
- Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices.Medical engineering & physics · 2017Article
- Comparison of Anticoagulant Effects of Nafamostat Mesilate and Heparin in Continuous Renal Replacement Therapy for Patients with High Bleeding Risk: A Meta-Analysis Systemic Review.Kidney diseases (Basel, Switzerland)Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
We systematically analyzed the relative contributions of frequency component elements of hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating devices as to overall platelet activation over time. We demonstrated that high frequency oscillations are the major determinants for priming, triggering and yielding activated "prothrombotic behavior" for stimulated platelets, even if the imparted shear stress has low magnitude and brief exposure time. Conversely, the low frequency components of the stress signal, with limited oscillations over time, did not induce significant activation, despite being of high magnitude and/or exposure time. In vitro data were compared with numerical predictions computed according to a recently proposed numerical model of shear-mediated platelet activation. The numerical model effectively resolved the correlation between platelet activation and the various frequency components examined. However, numerical predictions exhibited a different activation trend compared to experimental results for different time points of a stress activation sequence. With this study we provide a more fundamental understanding for the mechanobiological responsiveness of circulating platelets to the hemodynamic environment of cardiovascular devices, and the importance of these environments in mediating life-threatening thromboembolic complications associated with shear-mediated platelet activation. Experimental data will guide further optimization of the thromboresistance of cardiovascular implantable therapeutic devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.