ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Prior Cocaine Self-Administration Increases Response-Outcome Encoding That Is Divorced from Actions Selected in Dorsal Lateral Striatum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping.Brain research · 2022Article
- Overexpressing Histone Deacetylase 5 in Rat Dorsal Striatum Alters Reward-Guided Decision-Making and Associated Neural Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Fractionating the all-or-nothing definition of goal-directed and habitual decision-making.Journal of neuroscience research · 2020Review
- Prior cocaine self-administration impairs attention signals in anterior cingulate cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Expectancy-Related Changes in Dopaminergic Error Signals Are Impaired by Cocaine Self-Administration.Neuron · 2019Article
- Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Are Cocaine-Seeking "Habits" Necessary for the Development of Addiction-Like Behavior in Rats?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- What Can Recordings in the Striatum Tell Us about Associative Learning?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Dorsal lateral striatum (DLS) is a highly associative structure that encodes relationships among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known to be disrupted after chronic drug abuse; however, it remains unclear what neural signals in DLS are altered. Current theory suggests that drug use enhances stimulus-response processing at the expense of response-outcome encoding, but this has mostly been tested in simple behavioral tasks. Here, we investigated what neural correlates in DLS are affected by previous cocaine exposure as rats performed a complex reward-guided decision-making task in which predicted reward value was independently manipulated by changing the delay to or size of reward associated with a response direction across a series of trial blocks. After cocaine self-administration, rats exhibited stronger biases toward higher-value reward and firing in DLS more strongly represented action-outcome contingencies independent from actions subsequently taken rather than outcomes predicted by selected actions (chosen-outcome contingencies) and associations between stimuli and actions (stimulus-response contingencies). These results suggest that cocaine self-administration strengthens action-outcome encoding in rats (as opposed to chosen-outcome or stimulus-response encoding), which abnormally biases behavior toward valued reward when there is a choice between two options during reward-guided decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.