Evidence map›Paper›PMID 28694296›Full record

ArticleJournal of lipid research2017

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL.

Mikael Larsson, Christopher M Allan, Rachel S Jung, Patrick J Heizer, Anne P Beigneux, Stephen G Young, Loren G Fong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Biomedicines · 2024
    Review
  7. Apolipoprotein C3: form begets function.Journal of lipid research · 2024
    Review
  8. Review
  9. Quartet of APOCs and the Different Roles They Play in Diabetes.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mikael LarssonDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095. Electronic address: mlarsson@mednet.ucla.edu.
Christopher M AllanDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095.
Rachel S JungDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095.
Patrick J HeizerDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095.
Anne P BeigneuxDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095.
Stephen G YoungDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095. Electronic address: sgyoung@mednet.ucla.edu.
Loren G FongDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA 90095. Electronic address: lfong@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
NHLBI NIH HHS P01 HL090553
6 · The paper itself

Abstract

apoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bound, but instead is tightly bound to glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) on endothelial cells. Here, we revisited the effects of apoC-III on LPL, focusing on apoC-III's capacity to affect the activity of GPIHBP1-bound LPL. We found that TRLs from

Indexed as

AnimalsApolipoprotein C-IIICHO CellsCricetulusHumansHydrolysisLipoprotein LipaseMiceProtein BindingReceptors, LipoproteinTriglyceridesApolipoprotein C-IIIGPIHBP1 protein, humanGPI-HBP1 protein, mouseLipoprotein LipaseReceptors, LipoproteinTriglyceridesglycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1hypertriglyceridemialipoprotein lipase

Identifiers

PMID28694296
PMCPMC5580902
OpenAlexW2735302968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.