ArticleDevelopment (Cambridge, England)2017
Soluble APP functions as a vascular niche signal that controls adult neural stem cell number.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system.JCI insight · 2026Article
- PGC-1α Expands Neural Precursor Pool and Facilitates Cognitive Recovery Within AD Hippocampus Through the Regulation of Mitochondrial Dynamics.Molecular neurobiology · 2025Article
- Establishment and long-term expansion of adult hepatobiliary organoids co-cultured with liver endothelial cells.Heliyon · 2024Article
- Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury.Cell communication and signaling : CCS · 2024Article
- Review
- The Role and Mechanism of the Vascular Endothelial Niche in Diseases: A Review.Frontiers in physiology · 2022Review
- Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.APL bioengineering · 2021Review
- Cellular Mechanisms and Regulation of Quiescence.Developmental cell · 2020Review
- Deciphering the neuroprotective and neurogenic potential of soluble amyloid precursor protein alpha (sAPPα).Cellular and molecular life sciences : CMLS · 2020Review
- Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019Review
- Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved.Neural regeneration research · 2019Article
- Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.Molecular biology of the cell · 2019Article
- Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.Frontiers in neuroscience · 2018Article
- Endothelial cells maintain neural stem cells quiescent in their niche.Neuroscience · 2017Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The molecular mechanism by which NSC number is controlled in the neurogenic regions of the adult brain is not fully understood but it has been shown that vascular niche signals regulate neural stem cell (NSC) quiescence and growth. Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche signal in the subventricular zone (SVZ) of the lateral ventricle of the adult mouse brain. sAPP suppresses NSC growth in culture. Further
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.