ArticleClinical immunology (Orlando, Fla.)2017
Idiopathic T cell lymphopenia identified in New York State Newborn Screening.
Article in Clinical immunology (Orlando, Fla.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Newborn screening for severe combined immunodeficiency in the NHS newborn blood spot screening programme: a systematic review.Health technology assessment (Winchester, England) · 2026Pooled it
- Second-tier genetics improves newborn screening accuracy for SCID and other T cell deficiencies.Journal of human immunity · 2026Article
- Managing non-SCID T cell lymphopenia after TREC-based newborn screening.Journal of human immunity · 2026Article
- Incidence and risk factors for CMV and EBV infection in infants with low T-cell receptor excision circles on newborn screen.Clinical immunology (Orlando, Fla.) · 2025Article
- Natural history of infants with non-SCID T cell lymphopenia identified on newborn screen.Clinical immunology (Orlando, Fla.) · 2022Article
- Newborn Screening for Severe Combined Immunodeficiency: 10-Year Experience at a Single Referral Center (2009-2018).Journal of clinical immunology · 2021Article
- TREC Screening for WHIM Syndrome.Journal of clinical immunology · 2021Article
- Characterization of Infants with Idiopathic Transient and Persistent T Cell Lymphopenia Identified by Newborn Screening-a Single-Center Experience in New York State.Journal of clinical immunology · 2021Article
- SCID newborn screening: What we've learned.The Journal of allergy and clinical immunology · 2021Review
- When Screening for Severe Combined Immunodeficiency (SCID) with T Cell Receptor Excision Circles Is Not SCID: a Case-Based Review.Journal of clinical immunology · 2021Review
- Are All Primary Immunodeficiency Disorders Inborn Errors of Immunity?Frontiers in immunology · 2021Article
- Immunological Findings and Clinical Outcomes of Infants With Positive Newborn Screening for Severe Combined Immunodeficiency From a Tertiary Care Center in the U.S.Frontiers in immunology · 2021Article
- Retrospective Analysis of a New York Newborn Screen Severe Combined Immunodeficiency Referral Center.Journal of clinical immunology · 2020Article
- Abnormal Newborn Screen in a WHIM Syndrome Infant.Journal of clinical immunology · 2019Article
- MHC II deficient infant identified by newborn screening program for SCID.Immunologic research · 2018Article
- Newborn Screening for Severe Combined Immunodeficiency.Current allergy and asthma reports · 2018Review
- First Year of Israeli Newborn Screening for Severe Combined Immunodeficiency-Clinical Achievements and Insights.Frontiers in immunology · 2017Article
- A Practical Approach to Newborn Screening for Severe Combined Immunodeficiency Using the T Cell Receptor Excision Circle Assay.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
Quantification of T-cell receptor excision circles (TRECs) for newborn screening for SCID has advanced the diagnosis of severe combined immune deficiency (SCID). However, it has led to the identification of infants with T cell lymphopenia without known cause. The clinical characteristics, appropriate laboratory monitoring, and outcomes of patients remain unclear. We performed a retrospective review of clinical and laboratory studies for 26 infants collected from 7 New York State referral centers from 2010 to 2016 with low TRECs (mean, 70copies/μl) and subnormal CD3 counts (mean, 1150/cubicmm). Over time absolute CD3 counts increased in 17 and decreased in 9; 22 (85%) have done well clinically regardless of absolute T cell values. Additional infants with TCL will continue to be identified in newborn screening panels. While most patients seem to do well clinically, parameters for diagnosis and monitoring have yet to be formalized, and additional information needs to be collected, causes and outcomes reported.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.