ArticleNeurotoxicology2018
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Open access · greenAbstract read
In one paragraph
Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Reframing welders' parkinsonism: from the "idiopathic" label to biological causation and legal recognition.Annals of occupational and environmental medicine · 2026Review
- Cholinergic dysfunction in occupational manganese exposure.Neurotoxicology · 2025Article
- Delayed emergence of parkinson's disease after reversible manganese-induced parkinsonism: a case report.BMC neurology · 2025Article
- Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies.Toxicology reports · 2025Review
- Gut to brain: essential micronutrient and trace element manganese transport, function and toxicity.Frontiers in physiology · 2025Review
- Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024Review
- Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.Biomolecules · 2023Review
- Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging.Neurotoxicology · 2023Article
- Exposing the role of metals in neurological disorders: a focus on manganese.Trends in molecular medicine · 2022Review
- Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Depression and anxiety in a manganese-exposed community.Neurotoxicology · 2021Article
- Manganese and Movement Disorders: A Review.Journal of movement disorders · 2021Article
- Severity of parkinsonism associated with environmental manganese exposure.Environmental health : a global access science source · 2021Article
- Short Report: Using Targeted Urine Metabolomics to Distinguish Between Manganese Exposed and Unexposed Workers in a Small Occupational Cohort.Frontiers in public health · 2021Article
- [11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.Journal of occupational and environmental medicine · 2020Article
- Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.Clinics in geriatric medicine · 2020Review
- MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers.Journal of occupational and environmental medicine · 2019Article
- The reproducibility of urinary ions in manganese exposed workers.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2019Article
- Selective D2 receptor PET in manganese-exposed workers.Neurology · 2018Article
- Neurotoxicity of manganese: Indications for future research and public health intervention from the Manganese 2016 conference.Neurotoxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Susan R CriswellDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: criswells@neuro.wustl.edu.
Susan Searles NielsenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Mark WardenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Joel S PerlmutterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA; Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Stephen M MoerleinDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Hubert P FloresDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
John HuangProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, WA, USA; Department of Biostatistics, University of Washington, School of Public Health, Seattle, WA, USA.
Noah SeixasDepartment of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, WA, USA.
Harvey CheckowayDepartment of Family Medicine and Public Health, UC San Diego School of Medicine, La Jolla, CA, USA.
Brad A RacetteDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Washington University in St. Louis · USUniversity of Washington · USUniversity of California, San Diego · USUniversity of the Witwatersrand · ZA
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI GALLAGHER, EVAN P · 1987 to 2021
$51.2MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MImaging Biomarkers of Neurotoxicity in WeldersR01ES021488 · NIEHS · WASHINGTON UNIVERSITY · PI Brad A Racette · 2013 to 2026
$5.3MVALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONSR01NS058714 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2008 to 2016
$4.4MInteraction of alpha-synuclein and neurotoxicants with Mac1-NADPH oxidaseR01ES019277 · NIEHS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2011 to 2015
$2.0MEpidemiology and Biomarkers of Parkinsonism in WeldersK24ES017765 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2009 to 2018
$1.5MRESTING STATE FUNCTIONAL CONNECTIVITY MRI IN MANGANESE EXPOSED WELDERSK23ES021444 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2012 to 2016
$809kNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NIEHS NIH HHS K23 ES021444NIEHS NIH HHS K24 ES017765NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES019277NIEHS NIH HHS R01 ES021488NINDS NIH HHS R01 NS058714
Abstract
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neuronal function. 6-[
Indexed as
Occupational ExposureAdultCorpus StriatumCross-Sectional StudiesDihydroxyphenylalanineFemaleHumansMagnetic Resonance ImagingMaleManganese PoisoningMiddle AgedOccupational DiseasesParkinsonian DisordersPositron-Emission TomographyWeldingDihydroxyphenylalaninefluorodopa F 18[(18)F]FDOPA PETManganese
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.