ArticleBioorganic & medicinal chemistry2017
Selective opioid growth factor receptor antagonists based on a stilbene isostere.
Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Phytochemistry and Pharmacological Potential of the GenusPharmaceuticals (Basel, Switzerland) · 2026Review
- Naltrexone Has Variable and Schedule-Dependent Effects on Oral Squamous Cell Carcinoma Cells.International journal of molecular sciences · 2025Article
- Substitution of a triazole for the central olefin in biologically active stilbenes.Bioorganic & medicinal chemistry letters · 2022Article
- Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
As part of an ongoing drug development effort aimed at selective opioid receptor ligands based on the pawhuskin natural products we have synthesized a small set of amide isosteres. These amides were centered on lead compounds which are selective antagonists for the delta and kappa opioid receptors. The amide isomers revealed here show dramatically different activity from the parent stilbene compounds. Three of the isomers synthesized showed antagonist activity for the opioid growth factor (OGF)/opioid growth factor receptor (OGFR) axis which is involved in cellular and organ growth control. This cellular signaling mechanism is targeted by "low-dose" naltrexone therapy which is being tested clinically for multiple sclerosis, Crohn's disease, cancer, and wound healing disorders. The compounds described here are the first selective small molecule ligands for the OGF/OGFR system and will serve as important leads and probes for further study.
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Registered trials
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