Evidence map›Paper›PMID 28693826›Full record

ReviewTrends in genetics : TIG2017

Genome-wide Mapping of the Nucleosome Landscape by Micrococcal Nuclease and Chemical Mapping.

Lilien N Voong, Liqun Xi, Ji-Ping Wang, Xiaozhong Wang

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Dinochromosome Heterotermini with Telosomal Anchorages.International journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Mapping Nucleosome Location Using FS-Seq.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  9. Article
  10. Review
  11. The macro and micro of chromosome conformation capture.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Theory of Active Chromatin Remodeling.Physical review letters · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lilien N VoongDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Liqun XiDepartment of Statistics, Northwestern University, Evanston, IL 60208, USA.
Ji-Ping WangDepartment of Statistics, Northwestern University, Evanston, IL 60208, USA. Electronic address: jzwang@northwestern.edu.
Xiaozhong WangDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA. Electronic address: awang@northwestern.edu.
Northwestern University · US

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
A Computational Biology Approach to Mapping Nucleosomes in Stem CellsR01GM107177 · NIGMS · NORTHWESTERN UNIVERSITY · PI WANG, JI-PING, WANG, XIAOZHONG ALEC · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM107177NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Nucleosomes regulate the transcription output of the genome by occluding the underlying DNA sequences from DNA-binding proteins that must act on it. Knowledge of the precise locations of nucleosomes in the genome is thus essential towards understanding how transcription is regulated. Current nucleosome-mapping strategies involve digesting chromatin with nucleases or chemical cleavage followed by high-throughput sequencing. In this review, we compare the traditional micrococcal nuclease (MNase)-based approach with a chemical cleavage strategy, with discussion on the important insights each has uncovered about the role of nucleosomes in shaping transcriptional processes.

Indexed as

AnimalsCells, CulturedChromosome MappingHigh-Throughput Nucleotide SequencingMiceMicrococcal NucleaseNucleosomesTranscription, GeneticMicrococcal NucleaseNucleosomeschemical mappingchromatinMNasenucleosomestranscriptional regulation

Identifiers

PMID28693826
PMCPMC5536840
OpenAlexW2733604997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.