Evidence map›Paper›PMID 28693818›Full record

ArticleJournal of biomechanics2017

Arterial wall remodeling under sustained axial twisting in rats.

Guo-Liang Wang, Li-Yi Wang, Shao-Xiong Yang, Ping Zhang, Xiao-Hu Chen, Qing-Ping Yao, Xiao-Bo Gong, Ying-Xin Qi, Zong-Lai Jiang, Hai-Chao Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Guo-Liang WangInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Li-Yi WangInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Shao-Xiong YangDepartment of Engineering Mechanics, Shanghai Jiao Tong University, Shanghai 200240, China.
Ping ZhangInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Xiao-Hu ChenInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Qing-Ping YaoInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Xiao-Bo GongInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Engineering Mechanics, Shanghai Jiao Tong University, Shanghai 200240, China.
Ying-Xin QiInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Zong-Lai JiangInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: zljiang@sjtu.edu.cn.
Hai-Chao HanInstitute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA. Electronic address: hchan@utsa.edu.
Shanghai Jiao Tong University · CN

Funding

Biomechanical Mechanisms of Artery TortuosityR01HL095852 · NHLBI · UNIVERSITY OF TEXAS SAN ANTONIO · PI HAN, HAI-CHAO · 2010 to 2014
$1.8M
NHLBI NIH HHS R01 HL095852
6 · The paper itself

Abstract

Blood vessels often experience torsion along their axes and it is essential to understand their biological responses and wall remodeling under torsion. To this end, a rat model was developed to investigate the arterial wall remodeling under sustained axial twisting in vivo. Rat carotid arteries were twisted at 180° along the longitudinal axis through a surgical procedure and maintained for different durations up to 4weeks. The wall remodeling in these twisted arteries was examined using histology, immunohistochemistry and fluorescent microscopy. Our data showed that arteries remodeled under twisting in a time-dependent manner during the 4weeks post-surgery. Cell proliferation, MMP-2 and MMP-9 expressions, medial wall thickness and lumen diameter increased while collagen to elastin ratio decreased. The size and number of internal elastic lamina fenestrae increased with elongated shapes, while the endothelial cells elongated and aligned towards the blood flow direction gradually. These results demonstrated that sustained axial twisting results in artery remodeling in vivo. The rat carotid artery twisting model is an effective in vivo model for studying arterial wall remodeling under long-term torsion. These results enrich our understanding of vascular biology and arterial wall remodeling under mechanical stresses.

Indexed as

Models, BiologicalVascular RemodelingAnimalsCarotid ArteriesCollagenElastinEndothelial CellsMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Rats, Sprague-DawleyRegional Blood FlowStress, MechanicalCollagenElastinMatrix Metalloproteinase 2Matrix Metalloproteinase 9Artery twistCell proliferationEndothelial cellInternal elastic lamina, fenestrae, extracellular matrixMatrix metalloproteinaseRatShear stressTorsionWall remodeling

Identifiers

PMID28693818
PMCPMC5746051
OpenAlexW2627946771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.