Evidence map›Paper›PMID 28693594›Full record

Trial reportTrials2017

The impact of phosphate-balanced crystalloid infusion on acid-base homeostasis (PALANCE study): study protocol for a randomized controlled trial.

Judith-Irina Pagel, Nikolai Hulde, Tobias Kammerer, Michaela Schwarz, Daniel Chappell, Alexander Burges, Klaus Hofmann-Kiefer, Markus Rehm

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Judith-Irina PagelDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany. judith.pagel@med.uni-muenchen.de.ORCID 0000-0003-3605-955X
Nikolai HuldeDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany.
Tobias KammererDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany.
Michaela SchwarzDepartment of Anaesthesiology, Surgical Clinic of Munich-Bogenhausen, Munich, Germany.
Daniel ChappellDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany.
Alexander BurgesDepartment of Gynaecology, Hospital of the University of Munich, LMU, Munich, Germany.
Klaus Hofmann-KieferDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany.
Markus RehmDepartment of Anaesthesiology, Hospital of the University of Munich LMU, Marchioninistr. 15, 81377, Munich, Germany.
LMU Klinikum · DEMünchen Klinik Bogenhausen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to investigate the effects of a modified, balanced crystalloid including phosphate in a perioperative setting in order to maintain a stable electrolyte and acid-base homeostasis in the patient. METHODS/

designThis is a single-centre, open-label, randomized controlled trial involving two parallel groups of female patients comparing a perioperative infusion regime with sodium glycerophosphate and Jonosteril® (treatment group) or Jonosteril® (comparator) alone. The primary endpoint is to maintain a stable concentration of weak acids [A DISCUSSION: Perioperative fluid replacement with the use of currently available crystalloid preparations still fail to maintain a stable acid-base balance and experts agree that common balanced solutions are still not ideal. This study aims to investigate the effectivity and safety of a new crystalloid solution by adding sodium glycerophosphate to a standardized crystalloid preparation in order to maintain a balanced perioperative acid-base homeostasis.

trial registrationEudraCT number 201002422520 . Registered on 30 November 2010.

Indexed as

Acid-Base EquilibriumAcidosisBiomarkersClinical ProtocolsCrystalloid SolutionsFemaleFluid TherapyGermanyGlycerophosphatesHumansInfusions, IntravenousIsotonic SolutionsModels, BiologicalPerioperative CarePhosphatesPilot Projectsalpha-glycerophosphoric acidBiomarkersCrystalloid SolutionsGlycerophosphatesIsotonic SolutionsPhosphatesRehydration SolutionsAcid-base balanceFluid replacement therapyPhosphateStewart conceptWeak acids [A-]

Identifiers

PMID28693594
PMCPMC5504754
OpenAlexW2735314357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.