ArticlePediatric rheumatology online journal2017
Bone metabolism and inflammatory characteristics in 14 cases of chronic nonbacterial osteomyelitis.
Article in Pediatric rheumatology online journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis.Paediatric drugs · 2026Review
- Chronic nonbacterial osteomyelitis: a typical case and review.Frontiers in pediatrics · 2026Review
- Establishment and Validation of a Predictive Nomogram Model for Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.Therapeutic advances in musculoskeletal disease · 2025Article
- Primary chronic osteomyelitis of the jaw - a descriptive study of the condition and its occurrence in Sweden between 2012 and 2018.Acta odontologica Scandinavica · 2024Article
- Diagnostic Value of Whole-Body MRI in Pediatric Patients with Suspected Rheumatic Diseases.Medicina (Kaunas, Lithuania) · 2024Article
- Sterile osteomyelitis: a cardinal sign of autoinflammation.Reumatologia · 2024Review
- Chronic Recurrent Multifocal Osteomyelitis of the Hand: A Rare Pediatric Condition.Hand (New York, N.Y.) · 2021Review
- The Effect of Inflammation on Bone.Frontiers in physiology · 2020Review
- Chronic recurrent multifocal osteomyelitis-case report of two patients and review of literature.International journal of clinical rheumatology · 2019Article
- Unusual case of chronic recurrent multifocal osteomyelitis.Pediatric rheumatology online journal · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic nonbacterial osteomyelitis (CNO) is a multifocal autoinflammatory disease that often impairs daily life in children. This study aimed to investigate the bone metabolic and inflammatory characteristics of patients with CNO, and to assess the differences between responders and nonresponders to conservative treatment.
methodsWe investigated the clinical symptoms; laboratory data including inflammatory and bone metabolic biomarkers; and imaging findings from plain radiography, magnetic resonance imaging (MRI), fluorodeoxyglucose-positron emission tomography (FDG-PET), and dual-energy x-ray absorption (DEXA) in 14 patients with CNO. All patients underwent first-line treatment comprising systemic nonsteroidal anti-inflammatory drugs with or without bisphosphonate. According to the response to the first-line treatment, the patients were divided into the clinical remission/partial response group and the no response group. The differences in bone metabolic and inflammatory characteristics between the two groups were assessed.
resultsAll patients had low bone mineral density assessed with DEXA. The bone metabolic biomarkers (bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b) were increased in boys of all ages and in young girls. Multiple inflammatory regions were detected in all patients by using FDG-PET including asymptomatic regions. The no response group had higher immunoglobulin G (IgG) and a greater number of bone inflammatory lesions detected on MRI than the clinical remission/partial response group.
conclusionOur data indicate the involvement of abnormal bone turnover, necessity of whole-body scanning, and association of higher serum IgG levels and greater numbers of inflammatory lesions with prolonged disease activity in patients with CNO.
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