ArticleCritical care (London, England)2017
Protocol based invasive intracranial pressure monitoring in acute liver failure: feasibility, safety and impact on management.
Article in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Spontaneous Intracranial Hemorrhage in Liver Failure: A Case-Based Approach to Transplant Candidacy and Care.Cureus · 2026Article
- Rethinking pre-procedural coagulation management in acute liver failure and acute-on-chronic liver failure: The emerging role of rotational thromboelastometry.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Difficult extubation following recovery from acute liver failure: Use of point-of-care critical care assessment.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Intracranial pressure monitoring in the perioperative period of patients with acute liver failure undergoing orthotopic liver transplantation.World journal of transplantation · 2023Review
- Neurological monitoring and sedation protocols in the Liver Intensive Care Unit.Metabolic brain disease · 2022Review
- Hemorrhagic Complications of Invasive Intracranial Pressure Monitor Placement in Acute Liver Failure: Outcomes of a Single-Center Protocol and Comprehensive Literature Review.Neurocritical care · 2021Article
- Optic Nerve Sheath Diameter in Acute Liver Failure: A Prospective Cohort Study.GE Portuguese journal of gastroenterology · 2021Article
- Intensive Care Management of Acute Liver Failure: Considerations While Awaiting Liver Transplantation.Journal of clinical and translational hepatology · 2019Review
- Neurological Monitoring in Acute Liver Failure.Journal of clinical and experimental hepatology · 2018Review
- UPDATE IN HEPATIC ENCEPHALOPATHY - PART II.Journal of clinical and experimental hepatology · 2018Article
- Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.Neurocritical care · 2018Article
- Management of Acute Liver Failure: A Pediatric Perspective.Current pediatrics reports · 2018Review
- Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute liver failure (ALF) may result in elevated intracranial pressure (ICP). While invasive ICP monitoring (IICPM) may have a role in ALF management, these patients are typically coagulopathic and at risk for intracranial hemorrhage (ICH). Contemporary ICP monitoring techniques and coagulopathy reversal strategies may be associated with a lower risk of hemorrhage. Our objective was to evaluate the safety, feasibility, impact on clinical management and outcomes associated with protocol-directed use of IICPM in ALF.
methodsAdult patients admitted between June 2011 and October 2016, with ALF and grade-4 encephalopathy with a reasonable likelihood of survival, were eligible for IICPM. The coagulopathy reversal protocol included administration of recombinant Factor VIIa (rFVIIa) and desmopressin, a goal platelet count >50,000/mm
resultsA total of 24/37 patients (65%) with ALF underwent IICPM. The most common reason for exclusion was encephalopathy grade <4. Four patients underwent liver transplantation. There was one asymptomatic ICH following IICPM, in a patient who had an excellent outcome. Sustained intracranial hypertension occurred in 13/24 monitored patients (54%), 5/24 (21%) required extreme measures (TIL-4) for ICP control, which were successful in 4 patients: 12/24 patients (50%) died but only 4 deaths (17%) were attributed to intracranial hypertension. Six of the 8 survivors with 6-month follow up had good functional outcome (GOS >3).
conclusionsProtocol-directed use of IICPM in ALF is feasible, associated with a low incidence of serious complications and has a significant impact on clinical management.
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Registered trials
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