ArticleJournal of ovarian research2017
Impact of oocytes with CLCG on ICSI outcomes and their potential relation to pesticide exposure.
Article in Journal of ovarian research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Human Oocyte Morphology and Outcomes of Infertility Treatment: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Review
- Mature oocyte dysmorphisms may be associated with progesterone levels, mitochondrial DNA content, and vitality in luteal granulosa cells.Journal of assisted reproduction and genetics · 2024Article
- Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks.Frontiers in public health · 2024Review
- Article
- Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.Frontiers in public health · 2023Review
- The Molecular Quality and Mitochondrial Activity of Porcine Cumulus-Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions.International journal of molecular sciences · 2022Article
- Polycystic ovary syndrome phenotype does not have impact on oocyte morphology.Reproductive biology and endocrinology : RB&E · 2022Article
- Chronic oral exposure to pesticides and their consequences on metabolic regulation: role of the microbiota.European journal of nutrition · 2021Review
- Performance characteristics of the Mindray chemiluminescence anti-Müllerian hormone assay.Journal of clinical laboratory analysis · 2021Article
- Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study.Frontiers in endocrinology · 2021Article
- Thoughts on the popularity of ICSI.Journal of assisted reproduction and genetics · 2021Review
- The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF.Endocrine connections · 2020Review
- Sub-Saharan Africa total diet study in Benin, Cameroon, Mali and Nigeria: Pesticides occurrence in foods.Food chemistry: X · 2019Article
- Relationship between the positions of cytoplasmic granulation and the oocytes developmental potential in human.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a significant risk of decreased ICSI outcomes.
methodsThis retrospective study included 633 women who were part of an intracytoplasmic spermatozoa injection (ICSI) program between 2009 and 2011. The participants lived in the Picardy region of France and had been exposed to pesticides. The participants were divided in two groups based on prevalence of oocytes with CLCG (LCLCG [n = 83]: low prevalence of oocytes with CLCG under 25%. HCLCG [n = 68]: high prevalence of CLCG over 75%). The embryological and clinical outcomes were analysed for both groups and were calculated using the difference between the two values.
resultsResults for couples with HCLCG compared to LCLCG showed a decrease in embryo cleavage, ongoing pregnancy, and live birth rates (82%, 14%, 13% vs 99%, 32%, 30%, respectively).The early miscarriage rate was increased (47% vs 11%), with an OR of 3.1 (95%CI [2.1-4.1]). Due to high pesticide exposure (over 3000 g/ha), there is a higher risk of a resulting disturbed oocyte cohort with a high prevalence of CLCG over 75%.
conclusionThe high prevalence of oocytes with CLCG over 75% has a negative effect on embryos and the general ICSI clinical outcomes. Furthermore, a putative association between pesticide exposure and risk of CLCG was identified, justifying the need for further research and a potential need to find alternative assisted reproductive technologies for these couples.
trial registrationTabacfertimasc. ID number: ID2011-A00634-37 ; registered 2011/2/8.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.