ArticleDiagnostic pathology2017
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report.
Article in Diagnostic pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review.Insights into imaging · 2021Review
- Rare sites of breast cancer metastasis: a review.Translational cancer research · 2019Review
- A Late Recurrent Metastatic Breast Cancer Mimicking Primary Pancreatic Cancer: Case Report.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundInvasive pleomorphic lobular carcinoma (PLC) is an aggressive subtype of invasive lobular carcinoma of the breast, which has its own histopathological and biological features. The metastatic patterns for PLC are distinct from those of invasive ductal carcinoma. In addition, pancreatic metastasis from PLC is extremely rare. CASE PRESENTATION: We report a rare case of a 48-year-old woman presenting with clinical gastrointestinal symptoms and pancreatic metastasis of PLC. The pancreatic tumor was composed of pleomorphic tumor cells arranged in the form of solid sheets and nests and as single files, with frequent mitotic figures, nucleolar prominence, high nuclear to cytoplasmic ratio and loss of cohesion. The malignant cells were positive for p120 (cytoplasmic) and GATA3 and negative for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, E-cadherin, gross cystic disease fluid protein 15 and mammaglobin, which indicated a lobular carcinoma phenotype of the breast.
conclusionsTo the best of our knowledge, this is one of the few reported cases in the literature of pancreatic metastasis of invasive lobular carcinoma of the breast, of which the definitive diagnosis was obtained only after surgery. Rare metastasis sites should be considered, particularly, when a patient has a medical history of PLC.
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