Evidence map›Paper›PMID 28693487›Full record

ArticleBMC oral health2017

Apical periodontitis associates with cardiovascular diseases: a cross-sectional study from Sweden.

Eunice Virtanen, Tapio Nurmi, Per-Östen Söder, Stella Airila-Månsson, Birgitta Söder, Jukka H Meurman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  3. Prevalence of Apical Periodontitis, Alveolar Bone Loss, and Root-Filled Teeth Among Olympic Athletes.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Eunice VirtanenBiomedicum Helsinki, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, P.O.Box 63, Haartmaninkatu 8, FIN-00014, Helsinki, Finland. eunice.virtanen@helsinki.fi.ORCID http://orcid.org/0000-0002-1584-1369
Tapio NurmiBiomedicum Helsinki, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, P.O.Box 63, Haartmaninkatu 8, FIN-00014, Helsinki, Finland.
Per-Östen SöderDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Stella Airila-MånssonNordland County Council, Bodö, Norway.
Birgitta SöderDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Jukka H MeurmanBiomedicum Helsinki, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, P.O.Box 63, Haartmaninkatu 8, FIN-00014, Helsinki, Finland.
University of Helsinki · FIKarolinska Institutet · SENordland Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriodontal disease associates with systemic diseases but corresponding links regarding apical periodontitis (AP) are not so clear. Hence our aim was to study association between AP and the prevalence of systemic diseases in a study population from Sweden.

methodsThe subjects were 150 patients from a randomly selected epidemiological sample of 1676 individuals. 120 accepted to participate and their basic and clinical examination data were available for these secondary analyses where dental radiographs were used to record signs for endodontic treatments and AP. Periapical Index and modified Total Dental Index scores were calculated from the x-rays to classify the severity of AP and dental infection burden, respectively. Demographic and hospital record data were collected from the Swedish National Statistics Center. T-test, chi-square and univariate analysis of covariance (ANCOVA) and regressions analyses were used for statistics.

resultsOf the 120 patients 41% had AP and 61% had received endodontic treatments of which 52% were radiographically unsatisfactory. AP patients were older and half of them were smokers. AP and periodontitis often appeared in the same patient (32.5%). From all hospital diagnoses, cardiovascular diseases (CVD) were most common, showing 20.4% prevalence in AP patients. Regression analyses, controlled for age, gender, income, smoking and periodontitis, showed AP to associate with CVD with odds ratio 3.83 (95% confidence interval 1.18-12.40; p = 0.025).

conclusionsThe results confirmed our hypothesis by showing that AP statistically associated with cardiovascular diseases. The finding that subjects with AP also often had periodontitis indicates an increased oral inflammatory burden.

Indexed as

Analysis of VarianceCardiovascular DiseasesChi-Square DistributionCross-Sectional StudiesFemaleHumansMaleMiddle AgedPeriapical PeriodontitisSwedenApical periodontitisCardiovascular diseasesHospital carePeriodontitisSystemic diseases

Identifiers

PMID28693487
PMCPMC5504601
OpenAlexW2736101672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.