ArticleOncology letters2017
Identification of hub genes and pathways associated with bladder cancer based on co-expression network analysis.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.Bioscience reports · 2021Article
- A Novel IGLC2 Gene Linked With Prognosis of Triple-Negative Breast Cancer.Frontiers in oncology · 2021Article
- Article
- A novel gene signature combination improves the prediction of overall survival in urinary bladder cancer.Journal of Cancer · 2019Article
- Identification of Hub Genes Associated With Progression and Prognosis in Patients With Bladder Cancer.Frontiers in genetics · 2019Article
- LGALS4 as a Prognostic Factor in Urothelial Carcinoma of Bladder Affects Cell Functions.Technology in cancer research & treatment · 2019Article
- Article
- TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.American journal of translational research · 2018Article
- Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer.Journal of immunology research · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
The aim of the present study was to identify hub genes and signaling pathways associated with bladder cancer (BC) utilizing centrality analysis and pathway enrichment analysis. The differentially expressed genes (DEGs) were screened from the ArrayExpress database between normal subjects and BC patients. Co-expression networks of BC were constructed using differentially co-expressed genes and links, and hub genes were investigated by degree centrality analysis of co-expression networks in BC. The enriched signaling pathways were investigated by Kyoto Encyclopedia of Genes and Genomes database analysis based on the DEGs. The hub gene expression in BC tissues was validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting. A total of 329 DEGs were screened, including 147 upregulated and 182 downregulated genes. The co-expression network constructed between BC and normal controls consisted of 182 nodes and 434 edges, and the two genes in each gene pair were differentially co-expressed genes. Centrality analysis of co-expression networks suggested that the top 5 hub genes with high degree included
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