ArticlePloS one2017
Early first trimester peripheral blood cell microRNA predicts risk of preterm delivery in pregnant women: Proof of concept.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Association between miRNAs in serum at 10-14 gestational weeks and spontaneous preterm delivery.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Maternal Plasma miRNAs as Early Biomarkers of Moderate-to-Late-Preterm Birth.International journal of molecular sciences · 2024Article
- Predicting Spontaneous Preterm Birth Using the Immunome.Clinics in perinatology · 2024Review
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review.Archives of gynecology and obstetrics · 2023Review
- Risk Scoring Systems for Preterm Birth and Their Performance: A Systematic Review.Journal of clinical medicine · 2023Review
- Delivery prediction by quantitative analysis of four steroid metabolites with liquid chromatography tandem mass spectrometry in asymptomatic pregnant women.Annals of medicine · 2022Article
- First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth.International journal of molecular sciences · 2022Article
- Article
- First Trimester Prediction of Preterm Delivery in the Absence of Other Pregnancy-Related Complications Using Cardiovascular-Disease Associated MicroRNA Biomarkers.International journal of molecular sciences · 2022Article
- Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth.Frontiers in cell and developmental biology · 2022Article
- High-Throughput Sequencing of Circulating MicroRNAs in Plasma and Serum during Pregnancy Progression.Life (Basel, Switzerland) · 2021Article
- Early pregnancy prediction of spontaneous preterm birth before 32 completed weeks of pregnancy using plasma RNA: transcriptome discovery and initial validation of an RNA panel of markers.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review.European journal of obstetrics & gynecology and reproductive biology: X · 2020Review
- Exosomes as Messengers Between Mother and Fetus in Pregnancy.International journal of molecular sciences · 2020Review
- Review
- CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery.PloS one · 2020Article
- MicroRNAs isolated from peripheral blood in the first trimester predict spontaneous preterm birth.PloS one · 2020Article
- First Trimester Circulating MicroRNA Biomarkers Predictive of Subsequent Preterm Delivery and Cervical Shortening.Scientific reports · 2019Article
- Predicting the target genes of miRNAs in preterm via targetscore algorithm.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe investigated the capacity of first trimester peripheral blood mononuclear cell (PBMC) microRNA to determine risk of spontaneous preterm birth among pregnant women. STUDY
designThe study included 39 pregnant women with the following delivery outcomes: 25 with a full term delivery (38-42 weeks gestation) 14 with spontaneous preterm birth (<38 weeks gestation). Of the 14 women experiencing spontaneous preterm birth, 7 delivered at 34-<38 weeks gestation (late preterm) and 7 delivered at <34 weeks gestation (early preterm). Samples were collected at a mean of 7.9±3.0 weeks gestation. Quantitative rtPCR was performed on 30 selected microRNAs. MicroRNA Risk Scores were calculated and Area-Under the Curve-Receiver-Operational-Characteristic (AUC-ROC) curves derived.
resultsThe AUC-ROC for the group delivering preterm (<38 weeks) was 0.95 (p>0.0001). The AUC-ROC for early preterm group (<34 weeks) was 0.98 (p<0.0001) and the AUC-ROC for the late preterm group (34-<38 weeks) was 0.92 (p<0.0001).
conclusionQuantification of first trimester peripheral blood PBMC MicroRNA may provide sensitive and specific prediction of spontaneous preterm birth in pregnant women. Larger studies are needed for confirmation.
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Registered trials
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