ArticleDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2018
Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model.
Article in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Review
- S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.Burns & trauma · 2023Article
- Multi-Fidelity Gaussian Process Surrogate Modeling of Pediatric Tissue Expansion.Journal of biomechanical engineering · 2022Article
- Biological Cover Mitigates Disruption of the Dermal Structure in Mechanically Expanded Skin in a Porcine Model.International journal of molecular sciences · 2022Article
- Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching.Journal of cellular and molecular medicine · 2022Article
- The Geometry of Incompatibility in Growing Soft Tissues: Theory and Numerical Characterization.Journal of the mechanics and physics of solids · 2021Article
- Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells.Frontiers in cell and developmental biology · 2021Article
- Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression.Computer methods in applied mechanics and engineering · 2020Article
- Mechanical stretching stimulates growth of the basal layer and rete ridges in the epidermis.Journal of tissue engineering and regenerative medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch.
objectiveThe authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin. MATERIALS AND
methodsTwo minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal.
resultsDeformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity.
conclusionIsogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.