Evidence map›Paper›PMID 28692408›Full record

ArticleDevelopmental neurorehabilitation2018

Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury.

Jaclyn A Stephens, Cynthia F Salorio, Anita D Barber, Sarah R Risen, Stewart H Mostofsky, Stacy J Suskauer

Open access · greenAbstract read
In one paragraph

Article in Developmental neurorehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  13. Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jaclyn A Stephensa Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Cynthia F Salorioa Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Anita D Barberc Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research , Manhasset, NY, USA.
Sarah R Risend Department of Pediatric Neurology , Baylor College of Medicine , Texas Children's Hospital, Houston TX , USA.
Stewart H Mostofskya Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Stacy J Suskauera Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Kennedy Krieger Institute · USFeinstein Institute for Medical Research · USJohns Hopkins Medicine · USJohns Hopkins University · USTexas Children's Hospital · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VALLE, DAVID · 2014 to 2019
$7.9M
Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Research Training in Rehabilitation for Brain Injury and Neurological DisabilityT32HD007414 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Amy J. Bastian · 1991 to 2026
$6.3M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Study of White Matter Development in a Rodent Model of Perinatal Brain InjuryK08NS063956 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI · 2009 to 2013
$897k
Neural Basis of Recovery of Inhibitory Control After Pediatric TBIK23HD061611 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SUSKAUER, STACY JENNIFER MARCUS · 2009 to 2013
$669k
NCATS NIH HHS UL1 TR001079NICHD NIH HHS K23 HD061611NICHD NIH HHS T32 HD007414NICHD NIH HHS U54 HD079123NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH085328NINDS NIH HHS K08 NS063956NINDS NIH HHS L40 NS098410
6 · The paper itself

Abstract

PURPOSE AND

methodThis study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI).

resultsCompared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks.

conclusionCollectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.

Indexed as

AdolescentAgingBrain Injuries, TraumaticChildChronic DiseaseCohort StudiesExecutive FunctionFemaleHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleNerve NetNeural PathwaysPilot ProjectsFunctional neuroimagingmild traumatic brain injurymoderate traumatic brain injuryneural networksresponse inhibition

Identifiers

PMID28692408
PMCPMC5843556
OpenAlexW2735521735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.