Evidence map›Paper›PMID 28692379›Full record

ArticleCancer biology & therapy2017

Macrocyclic peptides decrease c-Myc protein levels and reduce prostate cancer cell growth.

Archana Mukhopadhyay, Laura E Hanold, Hamsa Thayele Purayil, Solomon A Gisemba, Sanjeewa N Senadheera, Jane V Aldrich

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Archana Mukhopadhyaya Department of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas , USA.ORCID http://orcid.org/0000-0001-5929-9877
Laura E Hanoldb Department of Medicinal Chemistry , University of Florida , Gainesville , Florida , USA.
Hamsa Thayele Purayilc Department of Anatomy and Cell Biology , University of Florida , Gainesville , Florida , USA.
Solomon A Gisembaa Department of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas , USA.
Sanjeewa N Senadheeraa Department of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas , USA.
Jane V Aldricha Department of Medicinal Chemistry , The University of Kansas , Lawrence , Kansas , USA.ORCID http://orcid.org/0000-0002-7954-9850
University of Kansas · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oncoprotein c-Myc is often overexpressed in cancer cells, and the stability of this protein has major significance in deciding the fate of a cell. Thus, targeting c-Myc levels is an attractive approach for developing therapeutic agents for cancer treatment. In this study, we report the anti-cancer activity of the macrocyclic peptides [D-Trp]CJ-15,208 (cyclo[Phe-D-Pro-Phe-D-Trp]) and the natural product CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]). [D-Trp]CJ-15,208 reduced c-Myc protein levels in prostate cancer cells and decreased cell proliferation with IC

Indexed as

ApoptosisCell ProliferationDown-RegulationHEK293 CellsHumansMalePeptides, CyclicPhosphorylationProstateProstatic NeoplasmsProto-Oncogene Proteins c-mycStereoisomerismTryptophanCJ 15,208MYC protein, humanPeptides, CyclicProto-Oncogene Proteins c-mycTryptophanapoptosiscell cycle arrestCJ-15,208c-Myc[D-Trp]CJ-15,208macrocyclic tetrapeptidesProstate cancer

Identifiers

PMID28692379
PMCPMC5652972
OpenAlexW2734898895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.