Evidence map›Paper›PMID 28692301›Full record

Trial reportAmerican journal of respiratory and critical care medicine2017

High-Dose Vitamin D

Davaasambuu Ganmaa, Baatar Munkhzul, Wafaie Fawzi, Donna Spiegelman, Walter C Willett, Purev Bayasgalan, Erkhembayar Baasansuren, Burneebaatar Buyankhishig, Sereeter Oyun-Erdene, David A Jolliffe and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Daily adjunctive therapy with vitamin DJournal of internal medicine · 2018
    Trial
  11. Article
  12. Vitamin D in pulmonary disease.Breathe (Sheffield, England) · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Davaasambuu Ganmaa1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Baatar Munkhzul3 National Center for Communicable Diseases, Ministry of Health, Mongolia National Center for Communicable Diseases Campus, Ulaanbaatar, Mongolia; and.
Wafaie Fawzi2 Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Donna Spiegelman1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Walter C Willett1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Purev Bayasgalan3 National Center for Communicable Diseases, Ministry of Health, Mongolia National Center for Communicable Diseases Campus, Ulaanbaatar, Mongolia; and.
Erkhembayar Baasansuren3 National Center for Communicable Diseases, Ministry of Health, Mongolia National Center for Communicable Diseases Campus, Ulaanbaatar, Mongolia; and.
Burneebaatar Buyankhishig3 National Center for Communicable Diseases, Ministry of Health, Mongolia National Center for Communicable Diseases Campus, Ulaanbaatar, Mongolia; and.
Sereeter Oyun-Erdene3 National Center for Communicable Diseases, Ministry of Health, Mongolia National Center for Communicable Diseases Campus, Ulaanbaatar, Mongolia; and.
David A Jolliffe4 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Theodoros Xenakis4 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Sabri Bromage2 Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Barry R Bloom2 Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Adrian R Martineau4 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
National Center for Communicable Diseases · MNBrigham and Women's Hospital · USHarvard University · USQueen Mary University of London · GB

Funding

Vitamin D supplementations as adjunct to anti-tuberculosis drugs in MongoliaK99HL089710 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DAVAASAMBUU, GANMAA · 2008 to 2009
$213k
NHLBI NIH HHS K99 HL089710
6 · The paper itself

Abstract

rationaleExisting trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking.

objectivesTo determine the effect of high-dose vitamin D

methodsWe conducted a clinical trial in 390 adults with PTB in Ulaanbaatar, Mongolia, who were randomized to receive four biweekly doses of 3.5 mg (140,000 IU) vitamin D MEASUREMENTS AND MAIN

resultsThe intervention elevated 8-week serum 25-hydroxyvitamin D concentrations (154.5 nmol/L vs. 15.2 nmol/L in active vs. placebo arms, respectively; 95% confidence interval for difference, 125.9-154.7 nmol/L; P < 0.001) but did not influence time to sputum culture conversion overall (adjusted hazard ratio, 1.09; 95% confidence interval, 0.86-1.36; P = 0.48). Adjunctive vitamin D

conclusionsVitamin D

Indexed as

AdultAntitubercular AgentsCholecalciferolDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMiddle AgedMongoliaPolymorphism, Single NucleotideSputumTreatment OutcomeTuberculosis, Pulmonary25-hydroxyvitamin DAntitubercular AgentsCholecalciferolVitamin DVitaminshost-directed therapypharmacogeneticssingle-nucleotide polymorphisms

Identifiers

PMID28692301
PMCPMC5620670
OpenAlexW2734785873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.