ArticleeLife2017
Effects of dopamine on reinforcement learning and consolidation in Parkinson's disease.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson's disease.Communications biology · 2025Trial
- Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication.Molecular psychiatry · 2023Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- A Mechanistic Understanding of the Different Factors Affecting Adaptation and Flexibility During Probabilistic Reversal Learning: A Neurocomputational Study on Patients with Parkinson's Disease and Control Subjects.Annals of biomedical engineering · 2026Article
- Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease.Movement disorders clinical practice · 2026Review
- Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
- Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) on cognitive flexibility.Molecular psychiatry · 2024Article
- Evaluating the Influence of Musical and Monetary Rewards on Decision Making through Computational Modelling.Behavioral sciences (Basel, Switzerland) · 2024Article
- Dopamine-independent effect of rewards on choices through hidden-state inference.Nature neuroscience · 2024Article
- Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning.eNeuro · 2024Article
- Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease.Frontiers in neuroscience · 2024Article
- Impulse control disorder in Parkinson's disease is associated with abnormal frontal value signalling.Brain : a journal of neurology · 2023Article
- Review
- Anterior cingulate and medial prefrontal cortex oscillations underlie learning alterations in trait anxiety in humans.Communications biology · 2023Article
- A failure of sleep-dependent consolidation of visuoperceptual procedural learning in young adults with ADHD.Translational psychiatry · 2022Article
- Reward learning and working memory: Effects of massed versus spaced training and post-learning delay period.Memory & cognition · 2022Article
- Acute stress blunts prediction error signals in the dorsal striatum during reinforcement learning.Neurobiology of stress · 2021Article
- Retention of Value Representations Across Time in People With Schizophrenia and Healthy Control Subjects.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decreased in memory accuracy over the following 24 hr. In contrast to previous studies, however, dopaminergic medication during learning and testing did not affect expression of positive or negative reinforcement. Two further experiments were run without the 24 hr delay, but they too failed to reproduce effects of dopaminergic medication on reinforcement learning. While supportive of a dopaminergic role in consolidation, this study failed to replicate previous findings on reinforcement learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.