Evidence map›Paper›PMID 28691550›Full record

Trial reportInternational journal of psychiatry in clinical practice2018

Relationships between obsessive-compulsive disorder, depression and functioning before and after exposure and response prevention therapy.

Sarosh J Motivala, Maria Arellano, Rebecca L Greco, David Aitken, Nathan Hutcheson, Reza Tadayonnejad, Joseph O'Neill, Jamie D Feusner

Erratum issuedOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of psychiatry in clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sarosh J Motivalaa Department of Psychiatry , University of California Los Angeles , Los Angeles , CA , USA.
Maria Arellanob Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
Rebecca L Grecob Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
David Aitkenb Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
Nathan Hutchesonb Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
Reza Tadayonnejadb Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
Joseph O'Neillb Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
Jamie D Feusnerb Semel Institute for Neuroscience and Human Behavior , University of California Los Angeles , Los Angeles , CA , USA.
University of California, Los Angeles · US

Funding

Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8M
Understanding the dynamics of visual processing abnormalities in body dysmorphic disorderR21MH110865 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2017 to 2018
$454k
NIMH NIH HHS R01 MH085900NIMH NIH HHS R01 MH105662NIMH NIH HHS R21 MH110865
6 · The paper itself

Abstract

objectiveObsessive-compulsive disorder (OCD) is associated with impaired functioning and depression. Our aim was to examine relationships between OCD symptoms, depression and functioning before and after exposure and response prevention (ERP), a type of cognitive-behavioural therapy for OCD, specifically examining whether functioning, depression and other cognitive factors like rumination and worry acted as mediators.

methodsForty-four individuals with OCD were randomised to 4 weeks of intensive ERP treatment first (n = 23) or waitlist then treatment (n = 21). We used a bootstrapping method to examine mediation models.

resultsOCD symptoms, depression and functioning significantly improved from pre- to post-intervention. Functioning mediated the relationship between OCD symptoms and depression and the relationship between functioning and depression was stronger at post-treatment. Depression mediated the relationship between OCD symptoms and functioning, but only at post-intervention. Similarly, rumination mediated the relationship between OCD symptoms and depression at post-intervention.

conclusionsOur findings suggest that after ERP, relationships between depression and functioning become stronger. Following ERP, treatment that focuses on depression and functioning, including medication management for depression, cognitive approaches targeting rumination, and behavioural activation to boost functionality may be important clinical interventions for OCD patients.

Indexed as

Outcome Assessment, Health CareAdultCognitive Behavioral TherapyDepressionFemaleHumansImplosive TherapyMaleMiddle AgedObsessive-Compulsive DisorderRumination, CognitiveCogntive-behavioural therapydepressionglobal functioningmediationobsessive-compulsive disorder

Identifiers

PMID28691550
PMCPMC5777899
OpenAlexW2725702475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.