ArticleAnnals of pediatric endocrinology & metabolism2017
Predictors of transient congenital hypothyroidism in children with eutopic thyroid gland.
Article in Annals of pediatric endocrinology & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- [Clinical guideline of «congenital hypothyroidism»].Problemy endokrinologii · 2022Guideline
- Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Levothyroxine use and discontinuation in presumed congenital hypothyroidism: a 10-year nationwide cohort study.Pediatric research · 2026Article
- Early prediction of transient versus permanent congenital hypothyroidism: a retrospective cohort study.Annals of pediatric endocrinology & metabolism · 2026Article
- Permanent or Transient Congenital Hypothyroidism: A Diagnostic Dilemma.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose.Clinical endocrinology · 2025Article
- Term birth and levothyroxine dosage are significant factors associated with permanent congenital hypothyroidism: experience from a medical center in Taiwan.BMC pediatrics · 2025Article
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- 50 YEARS OF NEWBORN SCREENING FOR CONGENITAL HYPOTHYROIDISM: EVOLUTION OF INSIGHTS IN ETIOLOGY, DIAGNOSIS AND MANAGEMENT: Transient or permanent congenital hypothyroidism: from milestones to current and future perspectives.European thyroid journal · 2025Review
- Predictive factors of permanent versus transient congenital hypothyroidism: a pragmatic cohort study.Annals of pediatric endocrinology & metabolism · 2025Article
- Predicting variables associated with diagnostic reevaluation of transient congenital hypothyroidism.Annals of pediatric endocrinology & metabolism · 2025Article
- Predictive Factors of Transient Congenital Hypothyroidism among Filipino Children: A Retrospective Study.Acta medica Philippina · 2025Article
- The natural course of newborns with transient congenital hypothyroidism.Endocrine connections · 2024Article
- High frequency of transient congenital hypothyroidism among infants referred for suspected congenital hypothyroidism from the Turkish National screening program: thyroxine dose may guide the prediction of transients.Journal of endocrinological investigation · 2024Observational
- Comparison between transient and permanent congenital hypothyroidism on a thyroid function test after re-evaluation.Annals of pediatric endocrinology & metabolism · 2023Article
- Evaluation of Transient or Permanent Congenital Hypothyroidism.Journal of clinical practice and research · 2023Review
- Prevalence of Transient Hypothyroidism in Children Diagnosed with Congenital Hypothyroidism between 2000 and 2016.International journal of molecular sciences · 2023Article
- Incidence of congenital hypothyroidism by gestational age: a retrospective observational study.Journal of Yeungnam medical science · 2023Article
- Guidelines for Newborn Screening of Congenital Hypothyroidism (2021 Revision).Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Article
- Knowns and unknowns about congenital hypothyroidism: 2022 update.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCongenital hypothyroidism (CH) is the most common cause of preventable mental retardation. Recently, the detection of CH cases with eutopic thyroid gland has increased due to neonatal screening programs. In this study, we aimed to identify and evaluate predictive factors that could distinguish between permanent and transient CH in patients with eutopic thyroid gland.
methodsWe retrospectively reviewed 100 children diagnosed with CH and with eutopic thyroid gland. All subjects were treated with levothyroxine and underwent re-evaluation after 3 years of age.
resultsOf the 100 CH patients, 35 (35.0%) were diagnosed with permanent CH (PCH) and 65 (65.0%) were diagnosed with transient CH (TCH). The initial thyroid stimulating hormone levels were significantly lower in the TCH subjects than in PCH subjects. In addition, the mean doses of levothyroxine (µg/kg/day) at the 1st, 2nd, and 3rd year of treatment were significantly lower in subjects with TCH than in PCH subjects with eutopic thyroid gland. Based on the receiver operating characteristic (ROC) curve, the optimal cutoff dose of levothyroxine at 3 years of 2.76 µg/kg/day could predict TCH, and was associated with 87.3% sensitivity and 67.6% specificity, with an area under the ROC curve of 0.769.
conclusionThe levothyroxine dose requirement during treatment period has a predictive role in differentiating TCH from PCH in CH patients with eutopic thyroid gland.
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