ReviewAnnals of pediatric endocrinology & metabolism2017
Metabolic syndrome induced by anticancer treatment in childhood cancer survivors.
Review in Annals of pediatric endocrinology & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Incidence of metabolic syndrome among radiation workers exposed to low dose radiation: a national cohort study in Korea.BMC public health · 2025Article
- Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients - A systematic review and Meta-Analysis.Clinical and translational radiation oncology · 2025Review
- Metabolic Sequelae and Quality of Life in Early Post-Treatment Period in Adolescents with Hodgkin Lymphoma.Journal of clinical medicine · 2025Article
- Sex/gender differences in metabolic syndrome among cancer survivors in the US: an NHANES analysis.Journal of cancer survivorship : research and practice · 2024Article
- Glycated albumin may have a complementary role to glycated hemoglobin in glucose monitoring in childhood acute leukemia.Annals of pediatric endocrinology & metabolism · 2024Article
- Commentary on "Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents".Annals of pediatric endocrinology & metabolism · 2024Article
- The evolving landscape of PCSK9 inhibition in cancer.European journal of pharmacology · 2023Review
- Fitness and metabolic response to exercise in young adult survivors of childhood lymphoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese.International journal of radiation biology · 2023Article
- Cardiovascular Risk in Childhood Cancer Survivors.Biomedicines · 2022Review
- Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative Review.Life (Basel, Switzerland) · 2021Review
- Metabolic syndrome and cardiovascular disease after haematopoietic cell transplantation (HCT) in adults: an EBMT cross-sectional non-interventional study.Bone marrow transplantation · 2021Article
- Review
- Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia.Indian pediatrics · 2021Article
- Body Composition Change, Unhealthy Lifestyles and Steroid Treatment as Predictor of Metabolic Risk in Non-Hodgkin's Lymphoma Survivors.Journal of personalized medicine · 2021Article
- Characterization of Cardiac, Vascular, and Metabolic Changes in Young Childhood Cancer Survivors.Frontiers in pediatrics · 2021Article
- Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients.Cancer management and research · 2021Review
- Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC).Antioxidants (Basel, Switzerland) · 2020Review
- Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia.Nutrients · 2020Article
- High Rates of Obesity at Presentation Persist into Survivorship across Childhood Cancer Types.Childhood obesity (Print) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of childhood cancer survivors is increasing as survival rates improve. However, complications after treatment have not received much attention, particularly metabolic syndrome. Metabolic syndrome comprises central obesity, dyslipidemia, hypertension, and insulin resistance, and cancer survivors have higher risks of cardiovascular events compared with the general population. The mechanism by which cancer treatment induces metabolic syndrome is unclear. However, its pathophysiology can be categorized based on the cancer treatment type administered. Brain surgery or radiotherapy may induce metabolic syndrome by damaging the hypothalamic-pituitary axis, which may induce pituitary hormone deficiencies. Local therapy administered to particular endocrine organs directly damages the organs and causes hormone deficiencies, which induce obesity and dyslipidemia leading to metabolic syndrome. Chemotherapeutic agents interfere with cell generation and growth, damage the vascular endothelial cells, and increase the cardiovascular risk. Moreover, chemotherapeutic agents induce oxidative stress, which also induces metabolic syndrome. Physical inactivity caused by cancer treatment or the cancer itself, dietary restrictions, and the frequent use of antibiotics may also be risk factors for metabolic syndrome. Since childhood cancer survivors with metabolic syndrome have higher risks of cardiovascular events at an earlier age, early interventions should be considered. The optimal timing of interventions and drug use has not been established, but lifestyle modifications and exercise interventions that begin during cancer treatment might be beneficial and tailored education and interventions that account for individual patients' circumstances are needed. This review evaluates the recent literature that describes metabolic syndrome in cancer survivors, with a focus on its pathophysiology.
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