Evidence map›Paper›PMID 28690980›Full record

ArticleFrontiers in cellular and infection microbiology2017

CRH Affects the Phenotypic Expression of Sepsis-Associated Virulence Factors by

Colette G Ngo Ndjom, Lindsay V Kantor, Harlan P Jones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Colette G Ngo NdjomDepartment of Molecular and Medical Genetics, University of North Texas Health Science CenterFort Worth, TX, United States.
Lindsay V KantorGraduate School of Biomedical Sciences, University of North Texas Health Science CenterFort Worth, TX, United States.
Harlan P JonesDepartment of Molecular and Medical Genetics, University of North Texas Health Science CenterFort Worth, TX, United States.
University of North Texas Health Science Center · USUniversity of North Texas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a life-threatening health condition caused by infectious pathogens of the respiratory tract, and accounts for 28-50% of annual deaths in the US alone. Current treatment regimen advocates the use of corticosteroids as adjunct treatment with antibiotics, for their broad inhibitory effect on the activity and production of pro-inflammatory mediators. However, despite their use, corticosteroids have not proven to be able to reverse the death incidence among septic patients. We have previously demonstrated the potential for neuroendocrine factors to directly influence

Indexed as

Anti-Bacterial AgentsBacterial CapsulesBacterial ProteinsBiomarkersCorticotropin-Releasing HormoneGene Expression Regulation, BacterialHumansPenicillin ResistancePhenotypePneumococcal InfectionsSepsisSerogroupShock, SepticStreptococcus pneumoniaeStreptolysinsVirulenceAnti-Bacterial AgentsBacterial ProteinsBiomarkersCorticotropin-Releasing HormoneplY protein, Streptococcus pneumoniaeStreptolysinsVirulence Factorscorticotropin releasing hormonephenotypesepsis virulenceserotypesStreptococcus pneumoniae

Identifiers

PMID28690980
PMCPMC5479890
OpenAlexW2657260971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.