ArticleJournal of intensive care2017
Is polymyxin B-immobilized fiber column ineffective for septic shock? A discussion on the press release for EUPHRATES trial.
Article in Journal of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Article
- Sepsis-Pathophysiology and Therapeutic Concepts.Frontiers in medicine · 2021Review
- Early use of endotoxin absorption by oXiris in abdominal septic shock: A case report.Medicine · 2020Article
- Cytokine removal in human septic shock: Where are we and where are we going?Annals of intensive care · 2019Review
- Colorectal Perforation in Patients with Connective Tissue Disease.Emergency medicine international · 2019Article
- The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS.Journal of intensive care · 2019Article
- Immune therapy in sepsis: Are we ready to try again?Journal of the Intensive Care Society · 2018Review
- Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls.Critical care (London, England) · 2018Review
- Efficacy of polymyxin B hemoperfusion in and beyond septic shock: is an "endotoxin severity score" needed?Critical care (London, England) · 2018Article
- Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids.Antibiotics (Basel, Switzerland) · 2018Article
- Polymyxin B hemoperfusion in septic shock: nothing overmuch (Meden Agan)!Journal of thoracic disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from "Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)" trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the "per protocol population" (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.